Animal Genomics

発表論文(太字は責任著者または筆頭著者)

2014
Saito H, Suzuki N
K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation
Biochemical and Biophysical Research Communications・452・1067-1070

Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Kakeda M, Okamoto R, Fujita S, Iwakura Y, Suzuki N, Ito M, Maruyama K, Gabazza EC, Yoshida T, Shimaoka M, Mizutani HPersistent Release of IL-1s from Skin Is Associated with Systemic Cardio-Vascular Disease, Emaciation and Systemic Amyloidosis: The Potential of Anti-IL-1 Therapy for Systemic Inflammatory Diseases
PLoS ONE・9・e104479　

Kayakabe M, Kakizaki T, Kaneko R, Sasaki A, Nakazato Y, Shibasaki K, Ishizaki Y, Saito H , Suzuki N, Furuya N, Yanagawa Y
Motor dysfunction in cerebellar Purkinje cell-specific vesicular GABA transporter knockout mice
Frontiers in Cellular Neuroscience）・7・286

2013
Thomanetz V, Angliker N, Cloetta D, Lustenberger RM, Schweighauser M, Oliveri F, Suzuki N, Ruegg MA
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
Journal of Cell Biology・201・293-308

Yamamura S, Hoshikawa M, Dai K, Saito H, Suzuki N, Niwa O, Okada MONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation
British Journal of Pharmacology・168・1088-1100

2012
Saito H, Yamamura K, Suzuki N
Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism
Disease Models & Mechanisms・46・397-406

D'Alessandro-Gabazza CN, Kobayashi T, Boveda-Ruiz D, Takagi T, Toda M, Gil-Bernabe MP, Miyake Y, Yasukawa A, Matsuda Y, Suzuki N, Saito H, Yano Y, Fukuda A, Hasegawa T, Toyobuku H, Rennard SI, Wagner PD, Morser J, Takei Y, Taguchi O, Gabazza EC
Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 Short Interfering RNAs for Pulmonary Fibrosis
American Journal of Respiratory Cell and Molecular Biology・46・397-406　　

2011
Takenaka N, Edamatsu H, Suzuki N, Saito H, Inoue Y, Oka M, Hu L, Kataoka TOverexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration
European journal of immunology・41・202-213

Ohnishi S, Saito H, Suzuki N, Ma N, Hiraku Y, Murata M, Kawanishi S
Nitrative and oxidative DNA damage caused by K-ras mutation in mice
Biochemical and Biophysical Research Communications・413・236-240

2010
Mizutani H, Okamoto R, Moriki N, Konishi K, Taniguchi M, Fujita S, Dohi K, Onishi K, Suzuki N, Satoh S, Makino N, Itoh T, Hartshorne DJ, Ito M
Overexpression of Myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function
Circulation Journal・74・120-128

2009
Saito H, Okada M, Miki T, Wakamori M, Futatsugi A, Mori Y, Mikoshiba K, Suzuki N
Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice
Biochemical and Biophysical Research Communications・390・1029-1033

Yamamura S, Saito H, Suzuki N, Kashimoto S, Hamaguchi T, Ohoyama K, Suzuki D, Kanehara S, Nakagawa M, Shiroyama T, Okada M
Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors
Neuroscience Letters・454・91-96

2007
Saito H, Yoshida T, Yamazaki H, Suzuki N.
Conditional N-rasG12V expression promotes manifestations of neurofibromatosis in a mouse model.
Oncogene・26(32) ・4714-9

2006
Tsumura H, Yoshida T, Saito H, Imanaka-Yoshida K, Suzuki N.
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice.
Oncogene・25(59):7673-9.

2005
Saito H, Tsumura H, Otake S, Nishida A, Furukawa T, Suzuki N.
L7/Pcp-2-specific expression of Cre recombinase using knock-in approach.
Biochem Biophys Res Commun. ・331(4):1216-21

Ryuji Okamoto, Masaaki Ito, Noboru Suzuki, Mariko Kongo, Nobuyuki Moriki, Hiromitsu Saito, Hideki Tsumura, Kyoko Imanaka-Yoshida, Kazushi Kimura, Akira Mizoguchi, David J. Hartshorne, Takeshi Nakano
The targeted disruption of the MYPT1 gene results in embryonic lethality.
Transgenic Res・14(3):337-40.

Tadano M, Edamatsu H, Minamisawa S, Yokoyama U, Ishikawa Y, Suzuki N, Saito H, Wu D, Masago-Toda M, Yamawaki-Kataoka Y, Setsu T, Terashima T, Maeda S, Satoh T, Kataoka T.
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase Ce.
Mol Cell Biol. ・25・ 2191-2199.

2004
Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, Kataoka T.
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Cancer Res・64, 8808-8810

Kulik A, Nakadate K, Hagiwara A, Fukazawa Y, Lujan R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R.
Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum.
Eur J Neurosci. 19, 2169-2178.

2003
Tsumura H, Suzuki N, Saito H, Kawano M, Otake S, Kozuka Y, Komada H, Tsurudome M, Ito Y.
The targeted disruption of the CD98 gene results in embryonic lethality.
Biochem Biophys Res Commun. 308, 847-851.

Suzuki N, Hirata M, Kondo S.
Traveling stripes on the skin of a mutant mouse.
Proc.Natl.Acad.Sci.USA. 100, 9680-9685
　　comment in Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9656-7.

Moriyama T, Iida T, Kobayashi K, Higashi T, Fukuoka T, Tsumura H, Leon C, Suzuki N, Inoue K, Gachet C, Noguchi K, Tominaga M.
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.
J Neurosci. 23, 6058-6062.

2002
Konishi H, Tsutsui H, Murakami T, Yumikura-Futatsugi S, Yamanaka K, Tanaka M, Iwakura Y, Suzuki N, Takeda K, Akira S, Nakanishi K, Mizutani H.
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Proc. Nat.l Acad. Sc.i U S A. 99, 11340-11345

1996
N. Suzuki ,P.A. Labosky, Y. Furuta, L. Hargett, R. Dunn, A.B. Fogo, K.Takahara, D.M.P. Peters, D.S. Greenspan, B.L.M. Hogan
Failure of ventral bodywall closure in mouse embryos lacking a procolagen C-proteinase encoded by Bmp1, a mammalian gene.related to Drosophila tolloid.
Development 122, 3587-3595.

K.Takahara, R.Brevard, G.G. Hoffman, N. Suzuki, D.S. Greenspan
Characterization of a novel gene product'(mammaliantolloid-like) with high sequence similarity to mammalian tolliod/bone morphogenetic protein-1.
Genomics 34, 157-165

1994
Fukagawa M, Suzuki N, Hogan BLM, Jones CM
Embryonic expression of mouse bone morphogentic protein-1(BMP-1) which is related to the Drosophila dorso-ventral gene tolloid and encodes a putative astasin metalloendopeptidaseDevelopmental Biology（Elsevier）・163・175-183

Minato T, Wang J, Akasaka K, Tomoyo T, Suzuki N, Kataoka T
Quantitative analysis of mutually competitive bindng of human Raf-1 and yeast adenylyl cyclase to Ras　proteins
Journal of Biological Chemistry・26・20845-20851

Hogan BLM, Blessing M, Winnier GE, Suzuki N, Jones CM
Growth factors in development: the role of TGF-s related polypeptide signaling molecules in embryogenesis
Development（Company Of Biologists Limited）・Supplement・53-60

1993
Wang J, Suzuki N, Nishida Y, Kataoka T
Analysis of the function of the 70-kilodalton cyclase-associated protein (CAP) by using mutants of yeast adenylyl cyclase defective in CAP binding
Molecular and Cellular Biology・13・4087-4097

Suzuki N, Tsujino K, Minato T, Nishida Y, Okada T, Kataoka T
Antibody mimicking the action of RAS proteins on yeast adenylyl Cyclase
Molecular and Cellular Biology・13・769-774

Kuroda Y, Suzuki N, Kataoka T
The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase
Science（The American Association for the Advancement of Science）・259　:683-686

Nazarea M, Saito Y, Okazaki S, Suzuki N, Honjo T
A Monoclonal Antibody which Inhibits Growth of T Cell Lines
Growth Factors（Informa Healthcare）・9・139-147

1992
Wang J, Suzuki N , Kataoka T
The 70 kDa CAP (adenylyl cyclase-associated protein) is not essential for interaction of Saccharomyces cerevisiae adenylyl cyclase with RAS proteins
Molecular and Cellular Biology・12・4937-4945

Horiguchi H, Kaibuchi K, Kawamura M, Matsuura Y, Suzuki N, Kuroda Y, Kataoka T, Takai Y
The posttranslational processing of of ras p21 is critical for stimulation of yeast adenylate cyclase
Molecular and Cellular Biology・12:4515-4520

1991
Mizuta TR, Suzuki N, Shimizu A, Honjo T
Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells
Journal of Biological Chemistry・266・12514-12521

1990
Suzuki N, Choe H-R, Nishida Y, Yamawaki-Kataoka Y, Ohnishi S, Tamanoki T, Kataoka T
Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins
Proceedings of the National Academy of Sciences of the United States of America・87・8711-8715

Kanamori H, Suzuki N, Shiomi H, Nosaka T, Sato A, Sabe H, Hatanaka M, Honjo T
HTLV-1 p27REX stabilizes human interleukin-2 receptor alpha chain mRNA
EMBO Journal （IRL Press）・9・4161-4166

1989
Sideras P, Mizuta TR, Kanamori H, Suzuki N, Okamoto M, Kuze K, Ohno H, Doi S, Fukuhara S, Hassan MS, Hammarstom L, Smith E, Shimizu A, Honjo T
Production of sterile transcription of C epsilon genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells
Internatioal Immunology・1・631-642

Kanamori H, Suzuki N, Ishida N, Honjo T
Transcriptional regulation alone dose not explain the constitutive expression of the interleukin-2 receptor (Tac/L chain) in HTLV-1 infected cells
Immunology Letters・20・293-298

1988
Saito Y, Sabe H, Suzuki N, Kondo S, Ogura T, Shimizu A, Honjo T
A larger number of L chains(Tac) enhance the associasion rate of interleukin 2 receptoｒ
Journal of Experimental Medicine・168・1563-1572

Ogura T, Konishi M, Suzuki N, Kondo S, Sabe H, Honjo T
Moleculer mechanism for the formation of the high-affinity complex of Interleukin 2 and its receptor
Molecular Biology & Medicine（Academic Press）・15・221-228

1987
Tagaya Y, Taniguchi Y, Naramura M, Okada M, Suzuki N, Kanamori H, Nikaido T, Honjo T, Yodoi J
Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines
Immunology Letters・15・221-228

Suzuki N, Matsunami N, Kanamori H, Isida N, Shimizu A, Yaoita Y, Nikaido T, Honjo T
The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts
Journal of Biological Chemistry・262・5079-5086

Matsunami N, Kanamori H, Suzuki N, Honjo T
Regulatory expression of the human interleukin-2 receptor gene: molecular basis for clonal expansion of lymphocytes
Integration and control of Metabolic processes: pure & applied aspects（ISCU Press）・197-209

1986
Kanamori H, Kondo S, Kinoshita M, Suzuki N, Saito Y, Sabe H, Matsunami N, Ishida N, Shimizu A, Honjo T
Interleukin-2 receptor: structure, function, and expression
Cold Spring Harbor symposia on quantitative biology・51・739-750

1985
Ishida N, Kanamori H, Noma T, Sabe H, Suzuki N, Shimizu A, Honjo T
Molecular cloning and structure of the human interleukin 2 receptor gene
Nucleic Acids Research（Oxford University Press）・13・7579-7589

Yamamura K, Miki T, Suzuki N, Ebihara T, Kawai K, Kumahara Y, Honjo TIntroduction of mouse C epsilon genes into Cos-7 cells and fertilized mouse eggsJournal of Biochemistry（Oxford University Press）・ 97・333-339

1984
Miki T, Suzuki N, Yamamura K, Hisajima H, Ueda S, Nishida Y, Takahashi T, Honjo T
Human Immunoglobulin Epsilon Gene
Immunogenetics: its application to clinical medicine（Academic Press）・227-238

Yoshida-Noro C, Suzuki N, Takeichi M
Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibodyDevelopmental Biology（Elsevier）・101・19-27