Research

Departments

Institute of Medical Life Science

Clinical Medical Sciences

Department Cardiology and Nephrology
Staff Masaaki ITO, MD, PhD, Professor
Norikazu YAMADA, MD, PhD, Associate Professor
Eitaro FUJII, MD, PhD, Lecturer
Kaoru DOHI, MD, PhD, Lecturer
Research Interests Both clinical and basic researches in the cardiovascular and renal fields are now currently carried. The projects in the Department of Cardiology and Nephrology are as follow:
(1) Clinical research in hemodynamics and neurohormonal regulation in patients with heart failure and/or cardiomyopathy.
(2) A thorough assessment of myocardial structure, function and perfusion by cardiac echo, CT and magnetic resonance imaging.
(3) Clinical research for risk assessment including hypertension, dyslipidemia, sleep apnea, diabetes and anemia for the prevention of atherosclerotic diseases and heart failure.
(4) Clinical research about outcome after revascularization against coronary and peripheral arterial diseases, and development of new cardiac catheterization therapies.
(5) Clinical research evaluating the effects of exercise training and DPP-4 inhibitors on exercise capacity and cardiovascular function in diabetic patients with myocardial infraction.
(6) The cohort study about the onset and management of myocardial infarction in Mie prefecture (MIE-ACS study).
(7) Molecular biology and pharmacology-based research in cardiovascular system and diseases, especially the researches for the regulation of vascular tone including systemic and pulmonary hypertension, and heart failure.
(8) Molecular research in cardiac hypertrophy and cardiomyopathy using genetically engineered mouse models and human iPS cells.
(9) Clinical research in electrophysiology including investigation of mechanisms of cardiac arrhythmias and developing new treatment approaches to tachyarrhythmias with drugs, electrical devices, catheter ablation.
(10) Clinical research in mechanism, diagnosis and treatment of pulmonary hypertension, pulmonary thromboembolism and deep vein thrombosis, and prevention of venous thromboembolism.
(11) Study of pathogenesis, treatment and prevention of progressive renal disease, such as immunoglobulin A nephropathy, diabetic nephropathy and nephrosclerosis.
(12) Study of genetic predisposing factors in chronic progressive renal disease.
(13) Clarification of the mechanism that accelerates aging in patients with chronic renal failure.
(14) Study of the osteoimmunology in hyperparathyroidism.
(15) Development of a new blood purification column.
(16) Development of new treatment for glomerulopathy by blood purification therapy.
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Department Hematology and Oncology
Staff Naoyuki Katayama , MD, PhD, Professor
Masahiro Masuya, MD, PhD, Associate Professor
Motoko Yamaguchi, MD, PhD, Assistant Professor
Toshirou Mizuno, MD, PhD, Assistant Professor
Research Interests The following investigations about hematological disorders and solid tumors are currently carried out to clarify their pathogenesis and develop new treatments.
(1) Investigation of the mechanism of human hematolymphopoiesis for cell therapy and regenerative medicine and for understanding of hematopoietic disorders, using newly-established coculture system.
(2) Elucidation of pathogenic mechanism in the development of inflammation, including graft versus host disease and organ fibrosis, and cancer through the analysis of the association of hematopoietic cells and factors in the microenvironment, such as chemokine and extracellular matrix.
(3) Analysis of clinicopathological features, immunophenotype, and gene expression profile of lymphomas
(4) Analysis of valuable predictive factors of response to drug therapy and those for prognosis in patients with solid tumors
(5) Clinical trials for hematopoietic disorders and solid tumors
(6) Clinical research about assessment and countermeasure to the adverse events associated with chemotherapy such as febrile neutropenia
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Department Gastroenterology and Hepatology
Staff Yoshiyuki TAKEI, MD, PhD, Professor
Motoh IWASA, MD, PhD, Associate Professor
Noriyuki HORIKI, PhD, Associate Professor
Hiroshi HASEGAWA, MD, PhD, Assistant Professor
Norihiko YAMAMOTO, MD, PhD, Assistant Professor
Research Interests We focus on the translational research (clinic to bench or bench to clinic) including liver, gut, gall bladder, pancreas, and organ-organ communication.
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Department Pulmonary and Critical Care Medicine
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Research Interests  
 
Department Diabetes, Metabolism and Endocrinology
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Research Interests  
 
Department Neurology
Staff Hidekazu TOMIMOTO, MD, PhD, Professor
Akira TANIGUCHI, MD, Lecturer
Yuichiro Ii, MD, PhD, Lecturer
Research Interests We are studying stroke and dementia, especially of vascular type,
focusing on
(1)Treatment and prevention of stroke
(2)Pathogenesis of vascular dementia and cerebral small vessel disease
In clinical setting, we are studying diagnosis and treatment of all type of ischemic stroke with the use of neuroradiological, physiological and immunochemical methodologies. Regarding on dementia, we have established animal model of vascular dementia, ie. a mouse model of chronic cerebral hypoperfusion, and are searching for the pathogenesis of vascular dementia. Indeed, we have succeeded to detect cortical microinfarcts on ultrahigh-field MRI, which should be a powerful tool for diagnosing cerebral amyloid angiopathy. Our research goal is early detection and prevention of stroke and dementia.
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Department Family Medicine and Community Medicine
Staff Yousuke TAKEMURA, MD, PhD, Professor
Hideki WAKABAYASHI, MD, PhD, MA, Lecturer
Tomohiro TAGUCHI, MD, Assistant Professor
Masaru KITAMURA, MD, Assistant Professor
Yohei Mori, MD, Assistant Professor
Shuhei ICHIKAWA, MInf, Assistant Professor
Satoshi Kondo, MD, Assistant Professor
Michiko Goto, PhD, Assistant Professor
Research Interests Our department is investigating several themes in family medicine, general practice, community medicine, and medical education. We especially focus on the behavioral aspects of patients and medical professionals. We use both quantitative and qualitative methods.
(1) Relationship between the basis of the family medicine and health outcome.
(2) To establish the method to build better team in medical setting
(3) Collaboration between primary care physician and occupational physician
(4) Cost-effectiveness of the home care
(5) Professionalism in physicians
(6) Science communication in medical setting
(7) Efficacy of the longitudinal clinical clerkship in local community
(8) Interprofessional education for students in medical school
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Department Neuropsychiatry
Staff Motohiro OKADA, MD, PhD, Professor
Hisashi TANII, MD, PhD, Associate Professor
Takashi SHIROYAMA, MD, PhD, Lecturer
Eishi MOTOMURA, MD, PhD, Lecturer
Research Interests To develop novel medications against psychiatric disorders and neurological disease, i.e. schizophrenia, bipolar disorder, anxiety disorder, autoimmune psychotic disease, epilepsy and Parkinson’s disease, we clarify the pathogenesis and pathophysiology of neuropsychiatric dysfunctions using neuro-psychological neuro-psycho-physiological, molecular biological clinical studies with neuro-psycho-pharmacological basic studies.
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Department Pediatrics
Staff Yoshihiro KOMADA, MD, PhD, Professor
Eiichi AZUMA, MD, PhD, Associate Professor
Hiroki HORI, MD, PhD, Professor
Masahiro HIRAYAMA, MD, PhD, Associate Professor
Yoshihide MITANI, MD, PhD, Associate Professor
Research Interests We are studying molecular and immunological mechanism on
(1) Childhood leukemogenesis, apoptosis and drug resistance.
(2) Applied anticancer treatment for refractory pediatric cancer, e.g.Neuroblastoma.
(3) GVHD and cell therapy after stem cell transplantation.
(4) Pulmonary hypertension and Kawasaki disease.
Moreover, our lab is the immunological diagnosis center of the Japanese Pediatric Leukemia/Lymphoma Study Group by flow cytometer. Our research goals are to investigate of the mechanism of Childhood Cancer and Pediatric heart disease to lead cure for kids in clinic.
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Department Dermatology
Staff Hitoshi Mizutani, MD., PhD., Professor
Keiichi Yamanaka, MD., PhD., Associate Professor
Kenichi Isoda, MD., PhD., Lecturer
Research Interests 1) Immunological investigation for atopic dermatitis, psoriasis, allergy and collagen diseases.
2) Investigation for cytokines in skin diseases. Mainly focusing IL-1 family cytokines.
3) Development of skin and systemic disease mouse models, and evaluation for their treatments.
4) Development of therapies for atopic dermatitis.
5) Evaluation of itching in human and mouse.
6) Dermatological scientific evaluation for various skin treatments including medicine, quasi drugs, cosmetics and toiletries.
7) Development for new strategies for skin disinfection and wound healing.
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Department Radiology
Staff Hajime SAKUMA, MD, PhD, Professor
Noriuki KATO, MD, PhD, Associate Professor
Masayuki MAEDA, MD, PhD, Associate Professor
Koichiro YAMAKADO, MD, PhD, Associate Professor
Shuichi MURASHIMA, MD, PhD, Lecturer
Research Interests Our research areas include advanced diagnostic imaging using 3T MRI and dual-source CT, nuclear medicine employing advanced PET-CT with cyclotron, Vascular and nonvascular interventional radiology (IVR), and radiation oncology. We are holding the leading positions in international societies as well as in Japan in the following research fields of Radiology.
(1) Cardiac MRI and CT, Coronary MR angiography and myocardial perfusion imaging
(2) Vascular IVR, Aortic stent grafting
(3) Non-Vascular IVR, Radiofrequency ablation and cryotherapy
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Department Molecular and Laboratory Medicine
Staff Hideo WADA, MD, PhD, Associate Professor
Naoki FUJIMOTO, MD, PhD, Lecturer
Research Interests We are studying and developing laboratory techniques to analyze the pathophysiology and molecular mechanisms of various diseases and to diagnose, monitor and predict these diseases.
1) Diagnosis, monitoring and treating disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP) and venous thromboembolism (VTE)
2) Diagnosis of thrombophilia and hemophilia by molecular biology
3) Monitoring antithrombotic therapy
4) Developing biomarkers for the evaluation of a hypercoagulable state
5) Prophylaxis for thrombosis and bleeding
6) Developing heart function tests and evaluating the results
7) Monitoring heart failure patients
8) Evaluating the risk factors for cardiovascular diseases
9) Diagnosing thrombosis based on imaging findings
10) Evaluating cardiac arrhythmia
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Department Clinical Pharmacy and Biopharmaceutics
Staff Masahiro OKUDA, PhD, Professor
Takuya IWAMOTO, PhD, Associate Professor
Research Interests For proper use of drugs and assurance of their efficacy and safety, we are studying basic and clinical research based on pharmacokinetics, cellular biology and epidemiology listed as follows.
1) Monitoring of drug blood concentration and accomplishment of optimal dosage regimen
2) Molecular mechanisms and clinical application of drug metabolizing enzymes and transporters
3) Exploration of factors and biomarkers associated with efficacy and side effects of drugs
4) Optimal dosage adjustment based on pharmacokinetics / pharmacodynamics (PK/PD) theory
5) Role and activity of clinical pharmacists in multidisciplinary team care
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Department Hepatobiliary Pancreatic and Transplant Surgery
Staff Shuji Isaji, MD, PhD:Professor and Chairman
Hiroyuki Sakurai, MD, PhD:Associate Professor
Masanobu Usui, MD, PhD:Associate Professor
Shugo Mizuno, MD, PhD:Assistant Professor
Masashi Kisiwada, MD, PhD: Assistant Professor
Yoshinori Azumi, MD, PhD: Assistant Professor
Naohisa Kuriyama, MD, PhD: Assistant Professor
Research Interests We are studying basic and clinical research related with hepatobiliary pancreatic and transplant surgery
(1) Liver transplant surgery: ischemic re-perfusion injury in rat model, influence of genotype on the pharmacokinetics of tacrolimus in LT patients
(2) Biliary surgery: effectiveness of preoperative chemotherapy for perihilar carcinoma, prognostic factors of biliary cancers (tumor budding, epithelial mesenchymal transition: EMT)
(3) Pancreatic surgery: effectiveness of preoperative chemoradiotherapy for pancreatic ductal adenocarcinoma, relationship between remnant pancreatic volume and its functions after pancreatectomy, Exploration of the effect of chemoradiotherapy on the expression of cancer associated extracellular matrix in locally advanced pancreatic cancer
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Department Gastrointestinal and Pediatric Surgery
Staff Masato KUSUNOKI, MD, PhD, Professor
Yasuhiko MOHRI, MD, PhD, Associate Professor
Yasuhiro INOUE, MD, PhD, Associate Professor
Toshimitsu ARAKI, MD, PhD, Associate Professor
Yuji TOIYAMA ,MD, PhD, Associate Professor
Research Interests Our department (gastrointestinal surgery) in Mie university has a broad research focus on understanding the molecular pathogenesis of human gastrointestinal cancer and inflammatory bowel disease. More specifically, the major objective of our research involves deciphering the interplay between genetic and epigenetic alterations in sporadic and familial forms colorectal cancer, colitis associated cancer and other gastrointestinal cancers (gastric and esophageal).
The broad mission of the research program is to:
Conduct high quality research into the pathogenesis of gastrointestinal cancers, inflammatory bowel disease and pediatric disease including malignancies.
Develop clinically useful biomarkers for the early detection of gastrointestinal cancers.
Develop clinically useful biomarkers that can help direct therapeutic treatments for patients with gastrointestinal cancers.
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Department Thoracic and Cardiovascular Surgery
Staff Hideto SHIMPO, MD, PhD, Professor
Takatsugu SHIMONO, MD, PhD, Associate Professor
Motoshi TAKAO, MD, PhD, Associate Professor
Hironori TEMPAKU, MD, PhD, Assistant Professor
Akira SHIMAMOTO, MD, PhD, Assistant Professor
Shinji KANEMITSU, MD, PhD, Assistant Professor
Research Interests Research provides the foundation for innovation and improvements in medicine and the cardiothoracic faculty lead and collaborate with investigative teams in basic science, translational research, clinical trials, and outcomes research, laying the groundwork for current and future improvements in patient care. This culture of medical education and research at Mie University translates to consistent access to the latest technology, medical advances, subspecialty expertise, and clinical trials that ultimately benefit all patients.
Especial our research interests are as follows: Pulmonary hypertension with congenital heart disease; Neointimal hyperplasia of graft failure at coronary artery bypass surgery; Drug-eluting stent graft for endovascular aortic aneurysm repair; Hematopoietic stem cell transplantation for thoracic aortic aneurysm; Vein graft adaptation for peripheral vascular surgery; Gene therapy for lung cancer: Lung ischemia-reperfusion injury at lung transplantation.
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Department Breast Surgery
Staff Tomoko OGAWA, MD, PhD, Professor
Noriko HANAMURA, MD, PhD, Assistant Professor
Research Interests Current Research
(1) Development of diagnostic imaging system for early stage breast cancer detect
(2) Development of a new method of image-guided biopsy for the diagnosis of minimal breast cancer
(3) Development and fundamental study of a new procedure of sentinel lymph node biopsy
(4) Development of a new procedure of oncoplastic surgery
(5) Fundamental study on tailor-made treatment for breast cancer: Relationship between gene-expression pattern and treatment outcome, and investigation of a new biomarker
(6) Fundamental study on carcinogenesis and metastasis of breast cancer
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Department Obstetrics and Gynecology
Staff Tomoaki Ikeda, MD, PhD, Professor and Chairman
Tsutomu Tabata, MD, PhD, Associate Professor
Toshiharu Okugawa, MD, PhD, Lecturer
Research Interests Research Content: Research content covers clinical and basic research which has been carried out in reproductive medicine, prenatal medicine and female genital malignancy.
(1)Elucidation of the cervical cancer carcinogenesis mechanism with research focused on inflammatory carcinogenesis by HPV.
(2)Clinical and basic research on the immunotherapy of ovarian cancer.
(3)Clinical research on ovarian cancer chemotherapy.
(4)A basic study on fertilization and implantation mechanisms.
(5)Study of lifestyle-related diseases pathogenesis after growth in intrauterine growth retardation children.
(6)Basic and clinical study of perinatal brain damage.
(7)Basic and clinical research on prevention and cause of death investigation of maternal mortality.
(8)Basic and clinical studies on diabetes mellitus pregnancy.
(9)Cardiotocography, basic and clinical research.
Guidance Content:
Training and guidance covers the research described above as well as biochemical, immunohistochemical analysis, gene analysis method, and pathological diagnosis. Clinical research covers analysis methods and implementation of clinical trials.
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Department Neurosurgery
Staff Hidenori SUZUKI, MD, PhD, Professor and Chairman
Toshio MATSUBARA, MD, PhD, Associate Professor
Masaki MIZUNO, MD, PhD, Associate Professor
Naoki TOMA, MD, PhD, Associate Professor
Research Interests Our program includes the clinical and basic science research for developing new techniques for diagnosis and treatment of neurosurgical diseases, such as vascular lesions, malignant and benign tumors, traumas, infections, malformations and functional diseases of the central nervous system.
Main Projects:
1) Molecular mechanisms of early brain injury and cerebral vasospasm after subarachnoid hemorrhage.
2) Development of devices for neuro-endovascular therapy.
3) Neuro-endovascular therapy for stroke and related diseases.
4) Computational flow dynamics (CFD) analysis of cerebral aneurysms concerning the growing and rupture risks.
5) Molecular mechanisms of epileptogenesis.
6) Development of new devices and techniques for spinal and peripheral nerve surgery.
7) Diagnostic imaging and multimodality therapy for malignant brain tumors.
8) Neuroendoscopic treatment of pituitary tumors and hydrocephalus.
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Department Orthopaedic Surgery
Staff Akihiro Sudo, MD, PhD, Professor
Masahiro Hasegawa, MD, PhD, Associate Professor
Hiroki Wakabayashi, MD, PhD
Koji Akeda, MD, PhD
Research Interests The Department of Orthopaedic Surgery, Mie University was established in 1951. We have mainly 6 divisions, and current clinical activities are focused on hip and knee joint surgeries, musculoskeletal tumor surgeries, spine surgeries, hand surgeries, rheumatoid arthritis, sport medicine, and bone metabolism.
Our department is also studying basic and clinical orthopaedic research focused on;
(1) Total hip and knee arthroplasties
(2) Musculoskeletal sarcomas and bone metastasis
(3) Microsurgery
(4) Osteoporosis
(5) Spinal Instrumentation
During these research fields, biomolecular and biomechanical engineering, 3D computer modeling, molecular imaging, in vivo and in vitro studies have been researched, and then these studies and surgical expertise coalesce to foster improved patient outcomes.
Our Orthopaedic Department upholds tradition by seeking answers and resolutions that will impact the diagnosis, treatment, and quality of life for orthopaedic and cancer patients.
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Department NEPHRO-UROLOGIC SURGERY AND ANDROLOGY
Staff Yoshiki Sugimura, MD, PhD, Professor
Kiminobu Arima, MD, PhD, Associate Professor
Hideki Kanda, MD, PhD, Assistant Professor
Research Interests We are studying molecular mechanisms on
(1) Embryogenesis and organogenesis of prostate gland
(2) Tissue remodeling in pathological conditions including benign hypertrophy (BPH) and cancer of prostate gland
(3) Stromal-epithelial interaction in normal and abnormal disease (cancer) of urogenital organ (prostate, bladder, kidney)
(4) Role of sex steroid hormone on prostate differentiation and growth
Our research goal is investigation of molecular mechanism in tumor microenvironment and development of novel stroma-targeted therapy for treatment of genitourinary cancer, specially castration-resistant prostate cancer (CRPC).
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Department Ophthalmology
Staff Mineo KONDO, MD, PhD, Professor
Kengo IKESUGI, MD, PhD, Associate Professor
Masahiko SUGIMOTO, MD, PhD, Associate Professor
Hisashi MATSUBARA, MD, PhD, Associate Professor
Research Interests Using electroretinogram (ERG) for the diagnosis of various retinal diseases – Prof. Kondo
Animal models of human retinal and optic nerve diseases analysed using ERG – Prof. Kondo
Glaucoma research(epidemiology, new class of drugs, surgery) – Dr. Ikesugi
Diabetic retinopathy research – Dr. Sugimoto
Ocular neovascularization regulated by extracellular matrix – Dr. Sugimoto
Treatments for age-related macular degeneration – Dr. Matsubara

In addition, almost all fields of clinical ophthalmology (e.g. corneal transplant, lacrimal passage, tear dynamics, pediatric ophthalmology, neuro-ophthalmology and low vision) will be considered as the subject of research, playing a role of the only university hospital in Mie Prefecture.
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Department Otorhinolaryngology-Head and Neck Surgery
Staff Kazuhiko TAKEUCHI, MD, PhD, Professor and Chairman
Masayoshi KOBAYASHI, MD, PhD, Associate Professor
Hajime ISHINAGA, MD, PhD, Assistant Professor
Research Interests The main interests of our department are defense mechanism of upper and lower airways in the normal and diseased states. The following subjects have been extensively studied.
1) Molecular mechanisms of airway mucus hypersecretion
Mucin gene expression and the effect of various drugs on the expression is examined using reporter gene assays.
2) Pathophysiology and treatment of allergic rhinitis
3) Primary ciliary dyskinesia
Electronmicroscopic studies of motile cilia and mutation analysis in the genes associated with ciliary movement are carried out in collaboration with affiliated facilities.
4) Pathophysiology and treatment of smell and taste disorders
5) Role of microRNAs in the development of head and neck carcinoma
6) Improvement of neural regeneration after olfactory system injury
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Department Oral and Maxillofacial Surgery
Staff Toshiro Tagawa, DDS, PhD, Professor
Madoka Inui, DDS, PhD, Associate Professor
Jouji Nomura, DDS, PhD, lecturer
Taku Murata, DDS, PhD, lecturer
Research Interests With the aim of elucidating the pathogenesis of oral diseases, developing and applying diagnostic and treatment modalities to oral diseases, and identifying the factors that promote oral tissue function, we are conducting research into the following areas:
(1) The intracellular signaling mechanisms of oral malignancies and gene therapy, photodynamic therapy, and diagnostic imaging (PET, MRI, 3D-CT) for these diseases
(2) The secretion mechanisms of salivary glands
(3) Early regeneration of bone defects induced by the application of BMP
(4) PDE expression in osteoblasts and the role of PDE in malignancies and salivary glands
(5) Dynamic MRI for temporomandibular joint disorder
(6) Biocompatibility of titanium and clinical findings relating to its use
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Department Anesthesiology and Critical Care Medicine
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Department Clinical Anesthesiology
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Department Emergency and Critical Care Medicine
Staff Hiroshi IMAI, MD, PhD, Professor
Taichi TAKEDA, MD, PhD, Associate professor
Masaki FUJIOKA, MD, PhD, Instructor
Tsuyoshi HATADA, MD, PhD, Instructor
Research Interests Introduction
The Emergency and Critical Care Center at our facility supports emergency medicine in Mie Prefecture by providing intensive care at stages from pre-hospital care to tertiary emergency care.
Our mission is to educate and train substantial numbers of emergency and intensive care physicians in Mie Prefecture.

Research areas
We plan and implement research in areas including:
1) Basic research and clinical application concerning blood coagulation and cellular adhesion in sepsis.
2) Research into ARDS-related respiratory therapies using mechanical ventilation, PCPS/ECMO, EIT (electrical impedance tomography), and other modalities.
3) Research into treatment for acute-phase DIC accompanying trauma or sepsis.
4) Research into therapeutic hypothermia for cerebrovascular damage after CPA and traumatic brain injury.
5) Research into prognostic factors in cardiopulmonary resuscitation.

We also participate actively in a variety of multicenter collaborative research projects, assisting efforts to improve the quality of emergency and intensive care in Japan and produce world-class data originating in Japan.
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Department

Pathology and Clinical Research in Internal Medicine

Staff Kojiro TAKASE, MD, Professor
Research Interests Overweight and life-style disease are closely related with eradication of Helicobacter pylori (H.P), which influences gastrointestinal hormone and gut flora. We are researching the following for these morbidity analyses.
(1) Changes in plasma ghrelin and leptin levels before and after eradiation of H.P .
The purpose of this research is to predict the onset of life-style disease induced by the weight increase following to H.P eradication, and eventually to prevent the onset of such disease by effectively controlling body weight.
(2) Gut flora in healthy person and patient with colon disease (colon cancer or colon adenoma).
If the occurrence of present/future colon disease can be predicted by investigating gut flora, and if the prognosis can be changed by the condition of the gut flora, control of the gut flora can be target of the prevention of colon diseases and the method of medical treatment.
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Department Neonatology
Staff Masaru IDO, MD, PhD, Professor
Hastumi YAMAMOTO, MD, PhD, Professor
Shigeki TANAKA, MD, PhD, Associate Professor
Motoki BONNO, MD, PhD, Associate Professor
Research Interests The Department of Neonatology focuses on the developmental immunology, genetic disorders and cognitive and behavior developmental science in the field of neonatology.
In our research on psychological development, we take two factors into consideration to study children’s healthy development; one is immaturity in neonatal period that has influences on the psychomotor development of the babies, and the other is their social and economical environment that affects children’s development and the onset of their disease.
Major research projects in our laboratory are as follows.
1.Elucidation of immunological feature in premature and mature neonate.
2.Elucidation of the immunological regulation in fertilization.
3.Elucidation of the molecular mechanism of congenital anomalies.
4.Analysis of the mechanism of signal transduction.
5.Elucidation of the factors which have effects on cognitive and behavior development of children.
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Department Child Medical Health and Development
Staff Toshiaki Ihara, M.D., Ph.D. , Professor
Takao Fujisawa, M.D., Ph.D., Professor
Shigeru Suga, M.D., Ph.D. , Associate Professor
Research Interests This division covers comprehensive and interdisciplinary medicine for children in the life cycle. Since many diseases are not restricted to certain age ranges and recent evidence shows that even senile diseases such as chronic obstructive lung disease or some kind of cancer start during childhood, the research in this division is oriented towards understanding of the pathophysiology of the diseases of childhood and adulthood over the life cycle. We also focus on global health problem where interdisciplinary effort is essential.
(Main research areas)
1) Infectious diseases: host defense mechanisms, development of vaccines, epidemiology of infectious diseases
2) Allergy and immunology: molecular mechanism of allergic diseases, clinical and translational studies for treatment of asthma and other allergic diseases
3) Metabolic diseases: clinical study on diabetes and obesity
4) Neurology: pathophysiology of intractable CNS diseases
5) Global Health: global epidemiology of infectious diseases, WHO projects for child health in developing countries
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Department Stress Science
Staff Teruhisa KOMORI, MD, PhD, Professor
Kayoko URAKAWA, MD, PhD, Professor
Research Interests We are studying mental stress and its reduction. In particular, we are focusing on
(1) Examination of utility of various strategies including music and fragrance
(2) Relapse prevention of psychiatric illness, sanitary education, regional support program and reinstatement support
(3) Psychoneuroimmunological research.

The stress is involved in various unhealthiness and illness of mind and body. The stress situation is examined from a psychoneuroimmunological viewpoint. The application of sense is promising in stress reduction and we are examined the effects of music and fragrance. In addition, the approach from many fields including education and regional support is examined, and the development of those effective programs is planned. The purpose of our research is to search for methods of stress reduction, and to contribute to the improvement of health.
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Department Health Promotion and Disease Prevention
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