Research

Departments

Institute of Medical Life Science

Community, Industry & Academic Research Alliances (Endowment Department)

Department Immuno-Gene Therapy
Staff Hiroshi SHIKU, MD, PhD, Professor
Shinichi KAGEYAMA, MD, PhD, Prpfessor
Takashi WATANABE, MD, PhD, Professor
Yoshihiro MIYAHARA, MD, PhD, Associate Professor
Naozumi HARADA, PhD, Assistant Professor
Naohiro SEO, PhD, Assistant Professor
Yasushi AKAHORI, PhD, Assistant Professor
Research Interests We are doing basic/translational and clinical research on cancer immunotherapy;
Our main studies are as follows;
(1) Clinical trials of adoptive TCR-T cell transfer targeting NY-ESO-1, MAGE-A4 and WT1 antigens (Phase 1).
(2) Clinical trials of CHP-NY-ESO-1 vaccine for post-surgical esophageal cancer patients (Phase 2) and CHP-NY-ESO-1 vaccine with MIS416 adjuvant for refractory bladder cancer and other cancer patients (Phase 1).
(3) Translational research of efficient cancer vaccine development using novel long peptide sequencing desigen
(4) Translational research of novel immunotherapy, TriCombo, for checkpoint inhibitor-resistant tumors
(5) Translational research of new CAR-T cell recognizing peptide/MHC complex, so that the CAR is able to recognize intra-cellular antigen.
(6) Basic research of T cell-derived exosomes and TCR identification that recognizes mutated tumor antigen
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Department Human Research Promotion and Drug Development
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Department Innovative Neuro-Intervention Radiology
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Department Systems Pharmacology
Staff Toshio Tanaka, MD, PhD, Professor
Research Interests The Systems Pharmacology of Mie University has particular strengths in the areas of zebrafish-based phenomics systems pharmacology on in vivo signaling mechanisms and gene expression as targets of drug action. Zebrafish-based drug discovery has become a potential strategy by its high throughput quantitative in vivo phenomics screening and has already succeeded in several examples of first-in–class or repositioning drug discovery. Systems pharmacology is defined to identify the gene network which are involved in determining the responsiveness and to distinguish responders and non-responders to a given drug. Genome sequensing, transcriptome, proteome and metabolome analysis are of particular significance in omics-based reverse systems pharmacology. We use multiomics analysis to identify and validate therapeutic target genes by studying change of gene expression in human cells and zebrafish model of various human diseases and find novel drug target candidates through our systems pharmacology strategy.
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Community- and Industry-based Innovative Research (Endowment Department)

Department Dementia Prevention and Therapeutics
Staff Professor: Hidekazu Tomimoto
Associate Professor: Masayuki Satoh
Research Interests Our department is the first one which specializes dementia research in national university. We perform not only medical research, but also arrangement of social systems which are indispensable for taking care of demented people at home. We investigate dementia, especially its vascular type, from the view-point of pathology, neuroanatomy, and neuropsychology.
We also carry out music therapy for demented people with collaboration of medical doctor and music therapist. Furthermore, we organize care conference on problematic cases of dementia, with the help of many clinic doctors, welfare professionals, and prefectural servants in order to build network for demented people. We believe that such multifaceted activities will be needed in Japan which is now becoming super-aging society.
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Department Cancer Vaccine
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Department Innovative Surgery and Surgical Techniques Development
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Department Orthopedics and Sports Medicine
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Department Spinal Surgery and Medical Engineering
Staff Yuichi KASAI, MD, PhD, Professor
Toshihiko SAKAKIBARA, MD, Assistant Professor
Research Interests We are doing as below.
1) Teaching various spinal surgeries
2) Studying chronic pain of musculoskeletal disorders
3) Researching spinal biomechanics
4) Making medical devices for commercialization
5) Supporting Myanmar spinal surgeries
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Department Clinical Cardiovascular Research
Staff Professor: Mashio Nakamura, MD, PhD
Professor: Masaaki Ito, MD, PhD
Research Interests The Department has conducted research on a wide variety of cardiovascular disease. Especially, we have carried on a collaborative clinical study with associated facilities for risk of CV disease (hypertension, dyslipidemia and impaired glucose tolerance) and venous thromboembolism.
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Cancer Professional Training Foundation Promoting Plan

Department Radiation Oncology
Staff Yoshihito NOMOTO, MD, PhD, Professor
Research Interests We are studying radiation oncology with biological, physical and clinical approach to eradicate cancers. Our main study themes are as follows.
Stereotactic body radiation therapy is curative radiation treatment option for local malignancy, from primary tumors to metastatic disease. It is carried out with use of precise delivery and higher doses of external beam radiation per treatment. We are studying optimal radiation dose and dose distribution for a cure with few complications.
Brachytherapy is useful method for dose concentration to tumor, and it is enabled with IGBT (Image Guided Brachytherapy) in radiation planning, recently. We are studying optimal radiation dose for uterine cervical cancer applying IGRT using MR image-guided optimization. We have developed an applicator for intraluminal irradiation for chest X ray negative lung cancer. We are investigating optimal dose fractionation and dose distribution to eradicate tumor with minimal damage of bronchial wall.
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Course of Nursing

Fundamental Nursing

Department Nursing Education
Staff Tomoko HAYASHI,RN,PhD,Professor
Kazumi IMURA,RN,PhD,Associate Professor
Research Interests

We are focusing the research on nursing education. It includes basic nursing education and continuing education as a system of lifelong education.

We develop curricula, programs, teaching and evaluation methods in nursing, and discuss the issues we face in nursing education. We are dedicated to the study of nurse-patient relationship, communication skills in nursing, the empathy and Emotional Intelligence (EI) of nurses and nursing students, nurse’s autonomy, and Interprofessional Education (IPE).

Our goal is to establish a trusting relationship between nurses and patients.
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Department Fundamental Clinical Nursing
Staff Yugo NARITA, MD, PhD, Professor
Nami IMAI, RN, PhD, Professor
Keiko FUKUROKU, RN, PHN, PhD, Associate Professor
Akiko HISADA, RN, MSN, Assistant Professor
Research Interests

Yugo NARITA, MD, PhD, Professor has been focusing appropriate assessment, and co-ordination of multidisciplinary services for patients with neurological disorders. Now, he is studying on NPO supporting system and communication devices for advanced ALS patients.


Nami IMAI RN, PhD, Professor
Dr.Imai is an active researcher in a field of human actions related the environment, and she talked about her researches at IPP-SHR interview at 2008 (listen to the web-site; Oncology Social Work Australia(OSWA) #52). She is managing to the Nursing Counseling Room (NCR) in the city of Tsu, Mie, Japan. Her research interest are pattern of behavior of sick building syndrome (SBS) and multiple chemical sensitivity (MCS) patients, expansion of nursing with SBS and MCS, establish EHN. She is inviting some earnest nurses who have interested in EHN as a graduate student.


Keiko FUKUROKU, RN, PHN, PhD, Associate Professor
We are studying on the intervention with exercise and effective support by nurses for elderly with musculoskeletal ambulation disorder symptom complex (MADS). Especially our aim is to develop a suitable support program on exercise adherence in community-based approach by co-operation with orthopedic clinics. We are studying on the association between ADL and walking ability improved by our exercise-intervention for elder patients with locomotive syndrome.

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Clinical Nursing

Department Oncology Nursing
Staff Mayumi TUJIKAWA, RN, PHN, PhD, Professor
Miwa ARAKI-SAKAGUCHI, RN, PHN, PhD, Associate Professor
Research Interests

We are interested in cancer nursing relating to prevention, treatment, palliative care, end of life care, and bereavement care for the cancer patients and their families. Especially we focus on integrated whole person care.

1. Quality of life(QOL) including the existential aspect of cancer survivors.
2. Holistic cancer nursing using complementary alternative medicine to improve their QOL.
3. Spiritual needs and care of the person in the end of life and one’s family.
4. Bereavement experience of family members and the bereavement care for the family.

This course has been selected as one of promotion plan for the platform of human resource development for cancer in Japan. The program for Certified Nurse Specialists (CNS) has been cultivating in this plan.

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Department Adult Health Nursing
Staff Kazue YOSHIDA, RN, WOCN, MBA, PhD, Associate Professor
Sachie TAKEUCHI, RN, DNS, Associate Professor
Research Interests

We are interested in following the recoveries of adult patients in the perioperative- or critical stage of health.

Our research focuses are the following:


1. We will study the adaptation of patients with stoma and describe supportive practices and educative nursing communication.

2. We will study unusual conditions of critical stage-patients and explore their needs and describe an educational strategy to improve the competence of nurses.


Our research goals are to intervene in remodeling the process of patients and to construct an educational model of competence in critical care nursing.

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Department Midwifery, Maternal and Newborn Nursing
Staff Atsuko ISEKI
Research Interests

We are studying women and maternal health, child care support based on reproductive health and rights.

Specifically, we will research on bioethics and women’s rights, mentality of infertile women, fetus diagnosis and reproductive technique, mother-infant interaction, and so on.

Our research aim to women’s health and QOL development, child health improvement.

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Department Child Health Nursing
Staff Kaori Nio, RN, phD, Professor
Mayumi Murabata, RN, PhD, Associate Professor
Research Interests

We are studying pediatric nursing dealing with children with chronic diseases or disabilities and their families. In particular, we are focusing on:

Research on nursing of children with congenital disease;
Research on support system for families and adolescents with chronic illness;
Research on independence of children with chronic illness;
Research on care of children with chronic illness;
Research on prevention of Clostridium difficile infection for children;
Research on protect children and their family from infe ction.

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Department Gerontological Nursing
Staff Tokiko ISOWA, RN, PhD, Professor
Mayuko HIRAMATSU, RN, Associate Professor
Research Interests

The department’s current studies are various issues on gerontological nursing and disaster nursing. 
The major topics are as follows;
1) Health promotion for elderly people in rural area
2) Disaster nurse’s role for elderly people and vulnerable populations
3) End-of-life care for elderly people with dementia
4) Psychoneuroimmunology on stress situation


In addition, we develop community activities focusing on health promotion for elderly people and vulnerable populations in underpopulated area as industry-government-academia research group. Our research goals are to establish more effective care systems for supporting the lives of elderly people.

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Community Health Nursing

Department Psychiatric Mental Health Nursing
Staff Kayoko Urakawa,RN,CP,MA,Ph.D, Professor
Research Interests I am focusing the research on psychiatric mental health nursing. It includes development of role and skills based on nursing theory by psychiatric nurses, mental health for workers on workplace, how to reduce stress of people, etc.
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Department Stress and Health Sciences
Staff Teruhisa KOMORI, MD, PhD, Professor
Research Interests

We are studying the stress reduction and the promotion of health. In particular, we are focusing on
(1)Stress reaction and its reduction
(2)Meaning of health from various viewpoint
(3)Vadility and problems of alternative medicine

The stress is involved in various unhealthiness and illness of mind and body. The stress situation and relaxation is examined from a psychoneuroimmunological viewpoint. The application of various means including aromatherapy and supplement is promising in stress reduction and in general medicine, but the clarification of these utilities is insufficient in a scientific manner yet. The ability to discern these from the scientific viewpoint and to take an appropriate part to the nursing practice is supported. The purpose of our research is to improve nursing practice ability through these researches.

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Department Public Health Nursing
Staff Hiroyo HATASHITA, PhD, Project Professor
Susumu TANIMURA, PhD, Professor
Ritsuko NISHIDE, M.A., Associate Professor
Research Interests Investigate the skills and strategies necessary to achieve effective, high quality nursing intervention and aid for all groups and individuals within the community in order to extend healthy life-spans, as well as contribute to health promotion from a long-term, global standpoint.

1. Research based on epidemiology and statistics to determine health related problems in groups.
1) Research on health and lifestyle in community residents.
2) Research on informatics and statistics education for nursing students.
3) Research on the diet and daily routines of infants and the parental activities of caregivers.
4) Research on the health of pregnant women and elementary aged schoolchildren exposed to secondhand smoking.

2. Research to establish methods and skills needed for public health nursing intervention.
1) Research to analyze and investigate how illness is dealt with and the medical needs of foreign residents in Japan from a cross-cultural standpoint, focusing on pregnancy, birth and childcare.
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