Ryoichi Ono, MD, PhD.
[研究テーマ]
白血病発症の分子機構の解析
[業績]
-Original
articles
(*,
corresponding author)
1. D'Alessandro-Gabazza CN, Yasuma T,
Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H,
Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, Fridman
D'Alessandro V, Shiraishi M, Mizoguchi A, Ono
R, Ohtsuka J, Fukumura M, Nosaka T, Mi X, Shukla D, Kataoka K, Kondoh
Y, Hirose M, Arai T, Inoue Y, Yano Y, Mackie RI, Cann I, Gabazza EC. Inhibition
of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation
of pulmonary fibrosis. Nat. Commun. 13:1558, 2022.
2. Ohtsuka J, Imai M, Fukumura M,
Maeda M, Eguchi A, Ono R,
Maemura T, Ito M, Yamayoshi S, Kataoka Y, Kawaoka Y, Nosaka T. Non-propagative
human parainfluenza virus type 2 nasal vaccine robustly protects the upper and
lower airways against SARS-CoV-2. iScience 24:103379, 2021.
3. Ono
R*, Masuya M, Inoue N, Shinmei M, Ishii S, Maegawa Y, Mahrjan
BD, Katayama N, Nosaka T. Tet1 is not
required for myeloid leukemogenesis by MLL-ENL
in novel mouse models. PLOS ONE 16:e0248425, 2021.
4. Sawaki A, Miyazaki K, Yamaguchi M,
Takeuchi T, Kobayashi K, Imai H, Tawara I, Ono
R, Nosaka T, Katayama N. Genetic polymorphisms and vincristine-induced
peripheral neuropathy in patients treated with rituximab, cyclophosphamide,
doxorubicin, vincristine, and prednisone therapy. Int. J. Hematol. 111:
686-691, 2020.
5. Maharjan BD, Ono R, Nosaka T. Eya2 is critical for the E2A-HLF-mediated immortalization of mouse
hematopoietic stem/progenitor cells. Int. J. Oncol. 54:981-990, 2019.
6. Ono
R*, Masuya M, Ishii S, Katayama N, Nosaka T. Eya2, a target activated
by Plzf, is critical for PLZF-RARA-induced
leukemogenesis. Mol. Cell. Biol., 37:e00585-16, 2017.
7. Takeuchi, T, Yamaguchi M, Kobayashi
K, Miyazaki K, Tawara I, Imai H, Ono
R, Nosaka T, Tanaka K, Katayama N. MYD88,
CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell
lymphoma. Cancer, 123:1166-1173, 2017.
8. Kobayashi K, Yamaguchi M, Miyazaki
K, Imai H, Yokoe K, Ono R,
Nosaka T, Katayama N. Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large
B-cell lymphoma cells and their association with clinical features. Cancer
Med., 5:1802-1809,
2016.
9. Ono
R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S,
Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T. Plzf drives MLL-fusion-mediated leukemogenesis
specifically in long-term hematopoietic stem cells. Blood, 122:1271-1283,
2013.
10. Shimozawa N, Ono R, Shimada M, Shibata H, Takahashi I, Inada H, Takada T,
Nosaka T, Yasutomi Y. Cynomolgus monkey induced pluripotent stem cells
established by using exogenous genes derived from the same monkey species. Differentiation,
85:131-139, 2013.
11. Liu B, Ohishi K, Orito Y,
Nakamori Y, Nishikawa H, Ino K, Suzuki K, Matsumoto T, Masuya M, Hamada H,
Mineno J, Ono R, Nosaka T,
Shiku H, Katayama N. Manipulation of human early T lymphopoiesis by coculture
on human bone marrow stromal cells: potential utility for adoptive
immunotherapy. Exp. Hematol., 41:367-376, 2013.
12. Suzuki K, Ono R, Ohishi K, Masuya M, Kataoka I, Liu B, Nakamori Y, Ino
K, Monma F, Hamada H, Kitamura T, Katayama N, Nosaka T. IKAROS isoform 6 enhances
BCR-ABL1-mediated proliferation of human CD34+hematopoietic cells on stromal
cells. Int. J. Oncol., 40: 53-62, 2012.
13. Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T,
Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y,
Kitamura T, Nosaka T. Expression of ADAMTS4 in Ewing's sarcoma. Int.
J. Oncol., 37:569-581, 2010.
14. Ono R, Kumagai H, Nakajima H,
Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T,
Nosaka T. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to
induce acute leukemia through aberrant Hox
expression and Raf activation. Leukemia, 23:2197-2209, 2009.
15. Jin G,
Matsushita H, Asai S, Tsukamoto H, Ono
R, Nosaka T, Yahata T, Takahashi S, Miyachi H. FLT3-ITD induces ara-C
resistance in myeloid leukemic cells through the repression of the ENT1
expression. Biochem. Biophys. Res. Commun., 390:1001-1006, 2009.
16.
Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T,
Kitaura J, Kitamura T. Possible involvement of RasGRP4 in leukemogenesis. Int.
J. Hematol., 89: 470-481, 2009.
17.
Watanabe-Okochi N, Kitaura J, Ono R,
Harada H, Harada Y, Komeno Y, Nakajima H, Nosaka T, Inaba T, and Kitamura T.
AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood,
111: 4297-4308, 2008.
18. Hiwatari M, Ono R,
Taki T, Hishiya A, Ishii E, Kitamura T, Hayashi Y, and Nosaka T. Novel
gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute
lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia, 22: 2279-2280,
2008.
19. Matsushita
H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R, Nosaka T, Sugita
K, Morimoto A, Hayashi Y, Hotta T, Ando K, and Miyachi H. C/EBPa and C/EBPe induce the monocytic
differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Oncogene, 27: 6749-6760, 2008.
20. Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima
T, Taki T, Kitamura T, Hayashi Y & Nosaka T. Dimerization of MLL
fusion proteins and FLT3 activation synergize to induce multiple-lineage
leukemogenesis. J. Clin. Invest., 115: 919-929, 2005.
21. Ono R, Ihara M,
Nakajima H, Ozaki K, Kataoka-Fujiwara Y, Taki T, Nagata K, Inagaki M, Yoshida
N, Kitamura T, Hayashi Y, Kinoshita M & Nosaka T. Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny,
leukemogenesis induced by MLL-SEPT6,
or phenotype induced by the loss of Sept4.
Mol.
Cell. Biol., 25: 10965-10978, 2005.
22. Taki T, Akiyama M, Saito S, Ono
R, Taniwaki M, Kato Y, Yuza Y, Eto Y & Hayashi Y. The MYO1F, unconventional myosin type 1F,
gene is fused to MLL in infant acute monocytic
leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22. Oncogene, 24: 5191-5197, 2005.
23.
Ono R, Taki T, Taketani T, Kawaguchi H, Taniwaki M, Okamura T,
Kawa K, Hanada R, Kobayashi M, & Hayashi Y. SEPTIN6, a human homolog to mouse Septin6, is fused to MLL
in infant acute myeloid leukemia with complex chromosomal abnormalities
involving 11q23 and Xq24. Cancer Res., 62: 333-337, 2002.
24.
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, & Hayashi
Y. LCX, leukemia-associated protein
with a CXXC domain, is fused to MLL
in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer
Res., 62: 4075-4080, 2002.
25. Taketani T, Taki T, Takita J, Ono R,
Horikoshi Y, Kaneko Y, Sako M, Hanada R, Hongo T, & Hayashi Y. Mutation of
the AML1/RUNX1 gene in a transient
myeloproliferative disorder patient with Down syndrome. Leukemia, 16: 1866-1867,
2002.
26. Taketani T, Taki T, Ono R, Kobayashi Y, Ida
K, & Hayashi Y. The chromosome translocation
t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98
gene with a HOXA cluster gene, HOXA13, but not HOXA9. Genes
Chromosomes Cancer, 34: 437-443, 2002.
27. Yamamoto K,
Nagata K, Tsurukubo Y, Inagaki K, Ono R, Taki T, Hayashi Y, &
Hamaguchi H. Translocation (8;12)(q13;p13) during disease progression in
acute myelomonocytic leukemia with t(11;19)(q23;p13.1). Cancer
Genet. Cytogenet., 137: 64-67, 2002.
-Review articles
1. 小埜良一、野阪哲哉. 血液腫瘍モデル動物の現状と展望. 日本臨床 78巻増刊3: 152-158, 2020.
2.
Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N,
Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y,
Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S,
Fukuyama T, Tanaka Y, Ono R,
Goyama S, Nosaka T, Kitaura J, & Inoue D. Novel working hypothesis for
pathogenesis of hematological malignancies: combination of mutations-induced
cellular phenotypes determines the disease (cMIP-DD). J. Biochem. 159:17-25,
2016.
3. 野阪哲哉、小埜良一. MLL融合遺伝子による白血病発症機構. 血液・腫瘍科,
61:217-223, 2010.
4. 小埜良一．MLL遺伝子再構成を有する小児白血病発症の分子機構．日小血会誌，21: 111-120, 2007.
5. 小埜良一，野阪哲哉．MLL関連白血病の分子病態．血液・腫瘍科，52: 615-624, 2006.
6. Ono
R, Nosaka T, & Hayashi Y. Roles of a trithorax group gene, MLL,
in hematopoiesis. Int J Hematol., 81: 288-293, 2005.
