Obeng G, Park EJ, Gaowa A, Shimaoka M. miRNA-200c targets talin-1 to regulate integrin-mediated cell adhesion. Sci Rep 2021 (in press)
Gaowa A, Park EJ, Kawamoto E, Qin Y, Shimaoka M. Recombinant soluble thrombomodulin accelerates epithelial stem cell proliferation in mouse intestinal organoids and promotes the mucosal healing in colitis. J Gastroenterol Hepatol. 2021. 2021 Aug 9. doi: 10.1111/jgh.15656. Online ahead of print.
Ito-Masui A, Kawamoto E, Esumi R, Imai H, Shimaoka M. Sociometric wearable devices for studying human behavior in corporate and healthcare workplaces. Biotechniques 2021 Jul;71(1):392-399.
Appiah MG, Park EJ, Darkwah S, Myint PK, Akama Y, Ito A, Obeng G, Kawamoto E, Gaowa A, Shimaoka M. Cellular and exosomal regulation of sepsis-induced metabolic alteration. Int J Mol Sci 2021. 22(15):8295.
Matsuo E, Okamoto T, Ito A, Kawamoto E, Asanuma K, Wada K, Shimaoka M, Takao M, Shimamoto A. Substrate stiffness modulates endothelial cell function via the YAP-Dll4-Notch1 pathway. Exp Cell Res 2021 408(1):112835
Sumiyoshi M, Kawamoto E, Nakamori Y, Esumi R, Ikejiri, K, Shinkai T, Akama, Y, Ito-Masui A, Imai H, Gaowa A, Park EJ, Shimaoka M. Elevated plasma soluble PD-L1 levels in out-of-hospital cardiac arrest patients. J Clin Med 2021, 10(18):4118
Kita K, Asanuma K, Okamoto T, Kawamoto E, Nakamura K, Hagi T, Nakamura T, Shimaoka M, Sudo A. Cytoskeletal actin structure in osteosarcoma cells determines metastatic phenotype via regulating cell stiffness, migration, and transmigration. Current Issues Mol Biol 2021, 43, 1255-1266.
Funao H, Tsujikawa M, Momosaki R, Shimaoka M. Virtual reality applied to home-visit rehabilitation for hemiplegic shoulder pain in a stroke patient: a case report. J Rural Med. 2021 Jul;16(3):174-178.
Yamamoto A, Wada H, Ichkawa Y, Tanaka M, Tashiro H, Shiraki K, Shimpo H, Yamashita Y, Mastumoto T, Shimaoka M, Iba T, Suzuki-Inoue K. Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation. J Clin Med. 2021 Jun 28;10(13):2860.
Nishigaki A, Ichikawa Y, Ezaki M, Yamamoto A, Suzuki K, Tachibana K, Kamon T, Horie S, Masuda J, Makino K, Shiraki K, Shimpo H, Shimaoka M, Suzuki-Inoue K, Wada H. Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction. J Clin Med. 2021 Jul 30;10(15):3408.
Wada H, Ichikawa Y, Ezaki M, Matsumoto T, Yamashita Y, Shiraki k, Shimaoka M, Shimpo H. The reevaluation of thrombin time using a clot waveform analysis. J Clin Med 2021 (in press)
Okamoto T, Park EJ, Kawamoto E, Usuda H, Wada K, Taguchi A, Shimaoka M. Endothelial connexin-integrin crosstalk in vascular inflammation. Biochim Biophys Acta Mol Basis Dis. 2021 May 13;1867(9):166168. doi: 10.1016/j.bbadis.2021.166168.
Park EJ, Myint PK, Appiah MG, Darkwah S, Caidengbate S, Ito A, Matsuo E, Kawamoto E, Gaowa A, Shimaoka M. The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells. Viruses. 2021 Apr 9;13(4):645. doi: 10.3390/v13040645.
Lee J, Mohsen A, Banerjee A, McCullough LD, Mizuguchi K, Shimaoka M, Kiyono H, Park EJ. Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice. Int J Mol Sci. 2021 Mar 29;22(7):3544. doi:10.3390/ijms22073544.
Hasegawa M, Tone S, Wada H, Naito Y, Matsumoto T, Yamashita Y, Shimaoka M, Sudo A. The Evaluation of Hemostatic Abnormalities Using a CWA-Small Amount Tissue Factor Induced FIX Activation Assay in Major Orthopedic Surgery Patients. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211012094. doi: 10.1177/10760296211012094.PMID: 34027710
Myint PK, Ito A, Appiah MG, Obeng G, Darkwah S, Kawamoto E, Gaowa A, Park EJ, Shimaoka M. Irisin supports integrin-mediated cell adhesion of lymphocytes. Biochem Biophys Rep. 2021 Feb 2;26:100932. doi: 10.1016/j.bbrep.2021.100932. eCollection 2021 Jul.
Ito-Masui A, Kawamoto E, Sakamoto R, Sano A, Motomura E, Tanii H, Sakano S, Esumi R, Imai H, Shimaoka M. Internet-based Individualized Cognitive Behavioral Therapy for Shift Work Sleep Disorder (Empowered by Wellbeing Prediction): A Pilot Study Protocol. JMIR Res Protoc. 2021 Mar 18;10(3):e24799. doi: 10.2196/24799.
Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto W, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M. Sepsis induces deregulation of IL-13 production and PD-1 expression in lung group 2 innate lymphoid cells. Shock 2021 Mar 1;55(3):357-370
Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Akama Y, Darkwah S, Appiah MG, Myint PK, Obeng G, Ito A, Caidengbate S, Esumi R, Yamaguchi T, Park EJ, Imai H, Shimaoka M. The lectin-like domain of thrombomodulin inhibits β1 integrin-dependent binding of human breast cancer cell-lines to fibronectin. Biomedicines 2021 Feb 7;9(2):162.
Park EJ*, Myint PK*, Appiah MG, Worawattananutai P, Inprasit J, Prajuabjinda O, Soe ZY, Gaowa A, Kawamoto E, Shimaoka M. Ligand-competent fractalkine receptor is expressed on exosomes. Biochem Biophys Rep 2021 Feb 2;26:100932.
Wada H, Shiraki K, Matsumoto T, Ohishi K, Shimpo H, Sakano Y, Nishii H, Shimaoka M. The Evaluation of APTT Reagents in Reference Plasma, Recombinant. FVIII Products; Kovaltry® and Jivi® Using CWA, Including sTF/7FIX Assay. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029620976913.
Kawamoto E, Park EJ, Shimaoka M. Methods to study integrin functions on exosomes. Methods Mol Biol. 2021;2217:265-281.
Wada H, Matsumoto T, Ohishi K, Shiraki K, Shimaoka M. Update on the Clot Waveform Analysis. Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620912027.
Darkwah S, Park EJ, Myint PK, Ito A, Appiah MG, Obeng G, Kawamoto E, Shimaoka M. Potential roles of muscle-derived extracellular vesicles in remodeling cellular microenvironment: proposed implications of the exercise-induced myokine, irisin. Front Cell Dev Biol. 2021 2021 Feb 5;9:634853
Yamaguchi T, Kawamoto E, Gaowa A, Shimaoka M. Roles of Leukemia Exosomal MicroRNAs and Integrins in Remodeling Bone Marrow Niches. Int J Mol Sci 2021. 22(4):1881.
Soe ZY, Park EJ, Shimaoka M. Integrin Regulation in Immunological and Cancerous Cells and Exosomes. Int J Mol Sci 2021. 22(4): 2198.
Nakamori Y, Park EJ, Shimaoka M. Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/PD-L1 pathway. Frontier Immunol 2021 Feb 17;11:624279. doi: 10.3389/fimmu.2020.624279. eCollection 2020.
2020年
Ito-Masui A, Kawamoto E, Nagai Y, Takagi Y, Ito M, Mizutani N, Yano K, Yano K, Imai H, Shimaoka M. Feasibility of Measuring Face-to-Face Interactions Among ICU Healthcare Professionals Using Wearable Sociometric Badges. Am J Respir Crit Care Med. 2020 Jan 15;201(2):245-247
Wada H, Shiraki K, Shimaoka M. The prothrombin time ratio is not a more effective marker for evaluating sepsis-induced coagulopathy than fibrin-related markers (letter). J Thromb Haemost 2020 Jun;18(6):1506-1507
Nago N, Yoneda M, Darkwah S, Kawamoto E, Park EP, Shimaoka M. Micro-MRI-based detection of tissue damage in the liver, pancreas, and kidney during the early phases of an LPS and D-galactosamine-induced hepatic injury model in mice. Diagn. Pathol Open 2020 5:161
Esumi R, Yokochi A, Shimaoka M, Kawamoto E. Virtual reality as a non-pharmacologic analgesic for fasciotomy wound infections in an acute compartment syndrome case. J Med Case Rep 2020 Apr 14;14(1):46
Wada H, Shiraki K, Matsumoto T, Ohishi K, Shimpo H, Shimaoka M. Effects of platelet and phospholipids on clot formation activated by a small amount of tissue factor. Thromb Res. 2020 Jun 10;193:146-153.
Wada H, Shiraki K, Shimaoka M. Errors in the diagnosis for DIC due to a statistical misunderstanding. J Thromb Haemost. 2020 Jul;18(7):1791-1792
Okamoto T, Kawamoto E, Usuda H, Nikai T, Asanuma K, Suzuki K, Shimaoka M, Wada K. Recombinant human soluble thrombomodulin suppresses monocyte adhesion by reducing lipopolysaccharide-induced endothelial cellular stiffening. Cells 2020. 9(8):1811
Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto W, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M. Sepsis induces deregulation of IL-13 production and PD-1 expression in lung group 2 innate lymphoid cells. Shock 2021 Mar 1;55(3):357-370
Wada H, Shirak K, Matsumoto T, Shimpo H, Yamashita Y, Shimaoka M. The evaluation of a scoring system for diagnosing atypical hemolytic uremic syndrome. Thrombosis Update. 2020 1:100012. https://doi.org/10.1016/j.tru.2020.100012
Appiah MG, Park EJ, Darkwah S, Kawamoto E, Akama Y, Gaowa A, Kalsan M, Ahmad S, Shimaoka M. Intestinal epithelium-derived luminally released extracellular vesicles in sepsis exhibit the ability to suppress TNF-alpha and IL-17A expression in mucosal inflammation Int J Mol Sci 2020. Nov 10;21(22):8445
Kawamoto E, Ito-Masui A, Esumi R, Imai H, Shimaoka M. Longitudinal association analysis of patient severity and face-to-face interactions between ICU healthcare professionals measured by wearable sociometric badges. Front Med (Lausanne). 2020 Dec 3;7:606987. doi: 10.3389/fmed.2020.606987. eCollection 2020.
Kawamoto E, Ito-Masui A, Esumi R, Ito M, Mizutani N, Hayashi T, Imai H, Shimaoka M. Social network analysis of ICU healthcare professionals measured by wearable sociometric badges. J Med Internet Res 2020 Dec 31;22(12):e23184.
Ichkawa Y, Wada H, Ezaki M, Tanaka M, Hiromori S, Shiraki K, Moritani I, Yamamoto A, Tashiro H, Shimpo H, Shimaoka M. Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients. Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620973084.
Myint PK, Park EJ, Gaowa A, Kawamoto E, Shimaoka M. Targeted remodeling of cancer and immune cell homing niches by exosomal integrins. Diagn. Pathol 2020 Apr 18;15(1):38
Wada H, Matsmoto T, Phnishi K, Shiraki K, Shimaoka M. Update on the clot waveform analysis. Clin Appl Thromb Hemost 2020. 26:1076029620912027
Yan Q, Gaowa A, Kawamoto E, Park EJ, Shimaoka M. Intestinal epithelial organoids: A platform for discovering mucosal healing drug candidates for the treatment of inflammatory bowel diseases. Diagn. Pathol Open 2020. 5:166
Park EJ, Myint PK, Ito A, Appiah MG, Darkwah S, Kawamoto E, Shimaoka M. Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights into the Multifaceted Roles of an Emerging Ligand Irisin. Front Cell Dev Biol 2020 Oct 26;8:588066
Akama Y, Satoh-Takayama N, Kawamoto E, Ito A, Gaowa A, Park EJ, Imai H, Shimaoka M. The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation. Diagnostics (Basel) 2020. 10(10):E808
Wada H, Matsumoto T, Ohishi K, Shiraki K, Shimaoka M. Update on the Clot Waveform Analysis. Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620912027.
2019年
Park EJ, Prajuabjinda O, Soe ZY, Darkwah S, Appiah MG, Kawamoto E, Momose F, Shiku H, Shimaoka M. Exosomal regulation of lymphocyte homing to the gut. Blood Adv. 2019 Jan 8;3(1):1-11
Soe ZY, Prajuabjinda O,Myint PK,Gaowa A, Kawamoto E, Park EJ, Shimaoka M. Talin-2 regulates integrin functions in exosomes. Biochem Biophys Res Commun. 2019 Mar 14. pii: S0006-291X(19)30404-8. doi: 10.1016/j.bbrc.2019.03.027. [Epub ahead of print]
Darkwah S, Nago N, Appiah MG, Kawamoto E, Shimaoka M, Park EJ. Differential roles of dendritic cells in expanding CD4 T cells in sepsis. Biomedicines 2019 18;7(3) E52
Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Sakakura Y, Akama Y, Soe ZY, Prajuabjinda O, Darkwah S, Appiah MG, Myint PK, Obeng G, Park EJ, Imai H, Shimaoka M. Anti-adhesive effects of human soluble thrombomodulin and its domains. Biochem Biophys Res Commun. 2019.
Kawamoto E, Masui-Ito A, Eguchi A, Soe ZY, Prajuabjinda O, Darkwah S, E Park EJ, Imai H, Shimaoka M. Integrin and PD-1 ligand expression on circulating extracellular vesicles in systemic inflammatory response syndrome and sepsis. Shock 2019 Jul;52(1):13-22. [Epub ahead of print]
Ikuno A, Akeda K, Takebayashi S, Shimaoka M, Okumura K, Sudo A. Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with humanintervertebral disc degeneration. PLoS One 2019 14(9):e0222188.
Shimaoka M, Kawamoto E, Gaowa A, Okamoto T, Park EJ. Connexins and Integrins in Exosomes. Cancers 2019 Jan 17;11(1)
Okamoto T, Usuda H, Tanaka T, Wada K, Shimaoka M. The functional implication for endothelial gap junction and cellular mechanics in vascular angiogenesis. Cancers 2019 Feb 18;11(2).
Koutsogiannaki S, Shimaoka M, Yuki K. The Use of Volatile anesthetics as sedatives for acute respiratory distress syndrome. Transl Perioper Pain Med. 2019;6(2):27-38. doi: 10.31480/2330-4871/084. Epub 2019. Feb 21.
Shimaoka M. Wearable-based objective measurement of expertness and happiness: its potential application for balneotherapy. J Balneol Climatol Phys Med 2019 82:20.
Park EJ, Appiah MG, Myint PK, Gaowa A, Kawamoto E, Shimaoka M. Exosomes in Sepsis and Inflammatory Tissue Injury. Curr Pharm Des. 2019 25(42):4486-4495.
Park EJ, Kawamoto E, Shimaoka M. Mucosal immunity for inflammation: regulation of gut-specific lymphocyte migration by integrins. In: Kiyono H, Pascual DW, editors. Mucosal Vaccines: Innovation for Preventing Infectious Diseases 2nd Edition. 85-100. Academic Press. 2019. London UK
2018年
Sakakura Y, Kamei M, Sakamoto R, Morii H, Itoh-Masui A, Kawamoto E, Imai H, Miyabe M, Shimaoka M. Biomechanical profiles of tracheal intubation: a mannequin-based study to make an objective assessment of clinical skills by expert anesthesiologists and novice residents. BMC Med Educ. 2018 Dec 4;18(1):293.
Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes DL, Shimaoka M, Springer TA, Dustin ML, Thrasher AJ, Burns SO. Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Wellcome Open Research. 2018. 3:84
Okamoto T, Takagi Y, Kawamoto E, Park EJ, Usuda H, Wada K, Shimaoka M. Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression. Exp Cell Res. 2018 Jun 15;367(2):264-273.
Yoshida K, Akita N, Okamoto T, Asanuma K, Uchida A, Sudo A, Shimaoka M, Suzuki K, Hayashi T. Activated protein C suppresses osteoclast differentiation via endothelial protein C receptor, protease-activated receptor-1, sphingosine 1-phosphate receptor, and apolipoprotein E receptor 2. Thromb Res. 2018 Mar;163:30-40.
2017年
Okamoto T, Kawamoto E, Takagi Y, Akita N, Hayashi T, Park EJ, Suzuki K, Shimaoka M. Gap junction-mediated regulation of endothelial cellular stiffness. Sci Rep. 2017 Jul 21;7(1):6134
Gayle A, Shimaoka M. Public Response to Scientific Misconduct: Assessing Changes in Public Sentiment Toward the Stimulus-Triggered Acquisition of Pluripotency (STAP) Cell Case via Twitter. JMIR Public Health Surveill. 2017 Apr 20;3
Gayle AA, Shimaoka M. Evaluating the lexico-grammatical differences in the writing of native and non-native speakers of English in peer-reviewed medical journals in the field of pediatric oncology: Creation of the genuine index scoring system. PLoS One. 2017 Feb 17;12(2):e0172338 (2):e21
Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 Apr 1;29(4);157-163.
2016年
Kawamoto E, Okamoto T, Takagi Y, Honda G, Suzuki K, Imai H, Shimaoka M.LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.Biochem Biophys Res Commun. 2016 473(4):1005-1012
2015年
Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H.Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 5:18174.
Akita N, Ma N, Okamoto T, Asanuma K, Yoshida K, Nishioka J, Shimaoka M, Suzuki K, Hayashi T. Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability. Thromb Res. 2015 135(6):1203-8.
Shimaoka M. (Guest editor). Current Topics in Sepsis. Cardiovasc Hematol Disord Drug Targets. 2015. 2015;15(1):1.
Shimaoka M. Strategic Career Planning for Physician-Scientists. J Orthopead Sci. 2015 2015 May;20(3):452-6.
2014年
Okamoto T, Akita N, Hayashi T, Suzuki K, Shimaoka M. Endothelial connexin32 enhances angiogenesis by positively regulating tube formation and cell migration. Exp Cell Res 2014. 321(2):133-41.
Kollmann CS, Bai X, Tsai C-H, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, and Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists Bioorg Med Chem 2014 22(7):2353-65
Okamoto T, Akita N, Hayashi T, Shimaoka M, Suzuki K. Endothelial connexin 32 regulates tissue factor expression induced by inflammatory stimulation and direct cell-cell interaction with activated cells. Atherosclerosis. 2014. 236(2): 430-7.
Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Kakeda M, Okamoto R, Fujita S, Iwakura Y, Suzuki N, Ito M, Maruyama K, Gabazza EC, Yoshida T, Shimaoka M, Mizutani H. Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases. PLoS One. 2014 9(8): e104479.
2013年
Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.Anesth Analg. 2013 117(4):803-11.
Yuki K, Bu W, Shimaoka M, Eckenhoff R. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3.PLoS One.2013;8(4):e60415.
Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 27(2):261-8.
2012年
Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG.Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.FASEB J. 2012 26(11):4408-17.
Banerjee D, Shimaoka M. Lentiviral gene transfer method to study integrin function in T lymphocytes. Methods Mol Biol. 2012; 757:47-54
Okamoto T, Tanigami H, Suzuki K, Shimaoka M. Thrombomodulin: a bi-functional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract 2012; 2012:614545. Epub 2012 Feb 28.
Maruyama K, Okamoto T, Shimaoka M. Integrins and Nitric Oxide in the Regulation of Glia Cells: Potential Roles in Pathological Pain. J Clin Anesth Res 2012 4:2 doi: 10.4172/2155-6105.S7-008
Tanigami H, Okamoto T, Yasue Y, Shimaoka M. Astroglial Integrins in the Development and Regulation of Neurovascular Units. Pain Res Treatment 2012;2012:964652. doi: 10.1155/2012/964652. Epub 2012 Dec 10.
Kawamoto E, Nakahashi S, Okamoto T, Imai H, Shimaoka M. Anti-integrin therapy for multiple sclerosis. Autoimmune Dis 2012;2012:357101. doi: 10.1155/2012/357101. Epub 2012 Dec 17.
〜2011年（抜粋）
Park EJ, Peixoto A, Imai Y, Goodarzi A, Cheng G, Carman CV, von Andrian UH, Shimaoka M. Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.Blood. 2010 115(8):1572-81. Epub 2009 Dec 18.
Eckenhoff RG, Xi J, Shimaoka M, Bhattacharji A, Covarrubias M, Dailey WP.Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane. ACS Chem Neurosci. 2010 1(2):139-145.
Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 16(9):1458-66.
Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M. Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.FASEB J. 2009 23(8):2735-40.
Imai Y, Park EJ, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV,Shimaoka M. Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins.Blood. 2008 Dec 15;112(13):5007-15. Epub 2008 Sep 22.
Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target.Science 2008 319(5863):627-30
Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH,Shimaoka M. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.J Clin Invest. 2007 Sep;117(9):2526-38.
Peer D, Zhu P, Carman CV, Lieberman J, Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4095-100. Epub 2007 Feb 28.
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R,Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell. 2003 Jan 10;112(1):99-111.
Imai Y, Shimaoka M, Kurokawa M. Essential roles of VLA-4 in the hematopoietic system. Int J Hematol. 2010 91(4):569-75.
Shimaoka M, Springer TA. Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov. 2003 Sep;2(9):703-16. Review.
邦文総説等 :
伊藤温志、赤間悠一、島岡要.免疫チェックポイントと２型自然リンパ球. Medical Science Digest 2021. 47(2):97-100.
Park EJ, Darkwah S, Appiah MG, Shimaoka M, Kiyono H. The mucosal immune system as a control mechanism of septic shock (敗血症性ショックの制御メカニズムとしての粘膜免疫系). Shock（日本Shock学会誌） 2020. 34(2): 44-64.