研究活動

研究実績

2016年

Ishikawa H, Kawada N, Taniguchi A, Odachi K, Mizutani A, Asahi M, Tomimoto H.
Paraneoplastic neurological syndrome due to burned-out testicular tumor showing hot cross-bun sign.

Acta Neurol Scand. 2016;133(5):398-402.

Shindo A, Liang AC, Maki T, Miyamoto N, Tomimoto H, Lo EH, Arai K.
Subcortical ischemic vascular disease: roles of oligodendrocyte function in experimental models of subcortical white-matter injury.

J Cereb Blood Flow Metab. 2016;36(1):187-98

Ueda Y, Satoh M, Tabei K, Kida H, Ii Y, Asahi M, Maeda M, Sakuma H, Tomimoto H
Neuropsychological Features of Microbleeds and Cortical Microinfarct Detected by High Resolution Magnetic Resonance Imaging.

J Alzheimers Dis. 2016;53(1):315-25

Mizuno T, Mizuta I, Tomimoto H.
Evaluation of NOTCH3 Pro167Ser Variation in a Japanese Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.

Dement Geriatr Cogn Disord Extra 2016;6183–184

Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K.
Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke.

Stroke. 2016;47(4):1094-100

Umino M, Maeda M, Ii Y, Tomimoto H, Sakuma H.
Low-signal-intensity rim on susceptibility-weighted imaging is not a specific finding to progressive multifocal leukoencephalopathy.

J Neurol Sci. 2016;362:155-9

Matsuura K, Maeda M, Tabei K, Umino M, Kajikawa H, Satoh M, Kida H, Tomimoto H.
A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson’s disease.

Neuroscience Letters 2016, 633:112–117

Sugiura M, Satoh M, Tabei KI, Saito T, Mori M, Abe M, Kida H, Maeda M, Sakuma H, Tomimoto H.
Detection of Low-Signal Pulvinar Areas Using Diffusion-Weighted Imaging in Patients with Dementia Experiencing Visual Hallucinations.

Dement Geriatr Cogn Dis Extra. 2016;6(3):458-464

Satoh M, Mori C, Matsuda K, Ueda Y, Tabei KI, Kida H, Tomimoto H.
Improved Necker Cube Drawing-Based Assessment Battery for Constructional Apraxia: The Mie Constructional Apraxia Scale (MCAS).

Dement Geriatr Cogn Dis Extra. 2016;6(3):424-436

Tabei KI, Satoh M, Nakano C, Ito A, Shimoji Y, Kida H, Sakuma H, Tomimoto H.
Improved Neural Processing Efficiency in a Chronic Aphasia Patient Following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study.

Front Neurol. 2016;7:148

Satoh M, Kato N, Tabei KI, Nakano C, Abe M, Fujita R, Kida H, Tomimoto H, Kondo K.
A case of musical anhedonia due to right putaminal hemorrhage: a disconnection syndrome between the auditory cortex and insula.

Neurocase. 2016;22(6):518-525

2015年

Matsuura K, TomimotoH. 
Istradefylline is recommended for morning use: a report of 4 cases. 

Internal Medicine,54:509-511,2015.

Tabei K, Satoh M, Kida H, Kizaki M, Sakuma H, Sakuma H, Tomimoto H.
Involvement of the Extrageniculate System in the Perception of Optical Illusions: A Functional Magnetic Resonance Imaging Study.

PLoS One;10(6):e0128750, 2015.

Tomimoto H. 
White matter integrity and cognitive dysfunction; radiological and neuropsychological correlations. 

Geriatrics & Gerontology International.2015;15(Suppl.1)3-9

Sakurai T, Tomimoto H, Pantoni L.

A new horizon of cerebral white matter hyperintensity in geriatric medicine. 

Geriatr Gerontol Int. 2015 ;Suppl 1:1-2. 

Iseki K, Fukuyama H, Oishi N, Tomimoto H, Otsuka Y, Nankaku M, Benninger D, Hallett M, Hanakawa T. 
Freezing of gait and white matter changes: a tract-based spatial statistics study. 

J Clin Mov Disord. 2015; 20;2:1 

Kamimoto Y, Wada H, Ikejiri M, Nakatani K, Sugiyama T, Osato K, Murabayashi N, Yamada N, Matsumoto T, Ohishi K, Ishikawa H, Tomimoto H, Ito M, Ikeda T. 
High frequency of decreased antithrombin level in pregnant women with thrombosis. 

Int J Hematol. 2015;102(3):253-8

Matsuura K, Maeda M,Okamoto K Araki T , Miura Y, Hamada K, Kanamaru K, Tomimoto H.

Usefulness of arterial spin-labeling images in periictal state diagnosis of epilepsy

J Neurol Sci. 2015 ;359(1-2):424-9

Tabei K, Satoh M, Kida H, Kizaki M, Sakuma H, Sakuma H, Tomimoto H.

Involvement of the Extrageniculate System in the Perception of Optical Illusions: A Functional Magnetic Resonance Imaging Study.  

PLoS One. 2015;10(6):e0128750.

Satoh M, Nagata K, Tomimoto H.

Sound Richness of Music Might Be Mediated by Color Perception: A PET Study. 

Behav Neurol. 2015;2015:241804

Yamazoe M, Maeda M, Umino M, Tomimoto H, Sakuma H   

Cerebral Microbleeds Identified by Susceptibility-Weighted Imaging in Two Cases of Fabry Disease without Neurological Symptoms

Open Journal of Medical Imaging, 2015, 5, 194-198

2014年

Yata K, Nishimura Y, Unekawa M, Tomita Y, Suzuki N, Tanaka T, Mizoguchi A, Tomimoto H. In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion.

Stroke. 2014;45(12):3698-703.

Tomimoto H , Wakita H. Animal models of vascular dementia: translational potential at the present time and in 2050'.

Future Neurology.2014;9(2):163-172.

Niwa A, Okamoto Y, Kondo T, Nabatame H, Takahashi R, Tomimoto H. Perivasculitic panencephalitis with relapsing polychondritis: an autopsy case report and review of previous cases.

Intern Med. 2014;53(11):1191-5.

Satoh M, Ogawa J, Tokita T, Nakaguchi N, Nakao K, Kida H, Tomimoto H. The effects of physical exercise with music on cognitive function of elderly people: Mihama-Kiho project.

PLoS One. 2014;25;9(4):e95230.

Shindo A, Wada H, Ishikawa H, Ito A, Asahi M, Ii Y, Ikejiri M, Tomimoto H. Clinical features and underlying causes of cerebral venous thrombosis in Japanese patients.

Int J Hematol. 2014;99(4):437-40.

Shindo A, Tanemura H, Yata K, Hamada K, Shibata M, Umeda Y, Asakura F, Toma N, Sakaida H, Fujisawa T, Taki W, Tomimoto H. Inflammatory Biomarkers in Atherosclerosis: Pentraxin 3 Can Become a Novel Marker of Plaque Vulnerability.

PLoS One. 2014;9(6):e100045.

Shindo A, Tanemura H, Yata K, Hamada K, Shibata M, Umeda Y, Asakura F, Toma N, Sakaida H, Fujisawa T, Taki W, Tomimoto H. Inflammatory Biomarkers in Atherosclerosis: Pentraxin 3 Can Become a Novel Marker of Plaque Vulnerability.

PLoS One. 2014;9(6):e100045.

Yata K, Tomimoto H. Chronic cerebral hypoperfusion and dementia

Neurology and Clinical Neuroscience.2014;2(5):129-134.

Ihara M, Taguchi A, Maki T, Washida K, Tomimoto H. A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment.

Methods Mol Biol. 2014;1135:95-102.

Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E. Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

Neurobiol Aging. 2014;35(1):213-22.

Miyagawa M, Maeda M, Umino M, Kagawa K, Nakamichi K, Sakuma H, Tomimoto H. Low signal intensity in U-fiber identified by susceptibility-weighted imaging in two cases of progressive multifocal leukoencephalopathy.

J Neurol Sci. 344(1-2):198-202.

田村 麻子, 佐々木 良元, 賀川 賢, 中谷 中, 小坂 仁, 冨本 秀和. 後方優位の白質脳症を呈し,葉酸をふくむビタミン投与が著効したメチレンテトラヒドロ葉酸還元酵素欠損症の1例.

臨床神経 54:200-206,2014

町野由佳,中山茂穂,冨本秀和 全身脱毛症をともなった多巣性脱髄性感覚運動型chronic inflammatory demyelinating polyradiculoneuropathy(CIDP)の1例

臨床神経 54:507-510,2014

伊藤 愛, 佐々木 良元, 朝日 理, 冨本 秀和 MRI拡散強調画像にて髄膜に高信号域をみとめたWegener肉芽腫症による軟膜・硬膜炎の1例

臨床神経 54:888-891,2014

[特許]冨本秀和、佐藤正之、木田博隆、田部井賢一、細谷 徹夫 情報処理装置及びコンピュータプログラム

特許出願2014-201890

2013年

Shindo A, Satoh M, Naito Y, Asahi M, Takashima S, Sasaki R, Furukawa K, Narita Y, Kuzuhara S, Tomimoto H. Global aphasia without hemiparesis: the underlying mechanism examined by transcranial magnetic stimulation.

Neurologist.2013;19(1):11-14.

Ii Y, Maeda M, Kida H, Matsuo K, Shindo A, Taniguchi A, Tomimoto H. In vivo detection of cortical microinfarcts on high-field MRI.

J Neuroimaging.2013;23:28-32.

Niwa A, Matsuo K, Shindo A, Yata K, Shiraishi T, Tomimoto H. Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene.

Neuropathology.2013;33,199–203.

Shindo A, Yata K, Sasaki R, Tomimoto H. Chronic cerebral ischemia induces redistribution and abnormal phosphorylation of transactivation-responsive DNA-binding protein-43 in mice.

Brain Res.2013;1533:131-140.

Nakamichi K, Kishida S, Tanaka K, Suganuma A, Sano Y, Sano H, Kanda T, Maeda N, Kira JI, Itoh A, Kato N, Tomimoto H, Kurane I, Lim CK, Mizusawa H, Saijo M. Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.

Arch Virol.2013;158(3):639-50.

Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T. Identification of a Novel Indoline Derivative for in Vivo Fluorescent Imaging of Blood-Brain Barrier Disruption in Animal Models.

ACS Chem Neurosci. 2013;4(8):1183-1193.

Matsuura K, Maeda M, Yata K, Ichiba Y, Yamaguchi T, Kanamaru K, Tomimoto H. Neuromelanin magnetic resonance imaging in Parkinson's disease and multiple system atrophy.

Eur Neurol.2013;70(1-2):70-77.

[特許]冨本秀和,佐藤正之,弓場徹,佐久間肇,竹田寛,水谷靖. 認知症の改善を支援するための装置、認知症の改善を支援するための方法、当該方法をコンピュータに実現させるためのプログラム.

特許出願 2013-185222

伊藤 愛, 佐々木 良元, 伊井 裕一郎, 中山 茂穂, 本村 政勝, 冨本 秀和. 胸腺腫を合併した抗筋特異的受容体チロシンキナーゼ抗体陽性重症筋無力症の1例.

臨床神経53:372-375,2013

佐々木 良元, 高橋 正紀, 穀内 洋介, 平山 正昭, 衣斐 達, 冨本 秀和, 望月 秀樹, 佐橋 功. 骨格筋型塩化物イオンチャネル遺伝子(CLCN1)の複合ヘテロ接合体変異で重症化したThomsen病.

臨床神経53:316-319,2013

2012年

Shindo A, Ikejiri M, Ii Y, Nakatani K, Wada H, Nobori T, Tomimoto H. A novel protein S gene mutation combined with protein S Tokushima mutation in a patient with superior sagittal sinus thrombosis.

J Neurol.2012;259(1):178-179.

Ikejiri M, Shindo A, Ii Y, Tomimoto H, Yamada N, Matsumoto T, Abe Y, Nakatani K, Nobori T, Wada H. Frequent association of thrombophilia in cerebral venous sinus thrombosis.

Int J Hematol.2012;95(3):257-62.

Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M. Selective white matter abnormalities in a novel rat model of vascular dementia.

Neurobiol Aging.2012;33(5)1012.e-25-35.

Komori M, Matsuyama Y, Nirasawa T, Thiele H, Becker M, Alexandrov T, Saida T, Tanaka M, Matsuo H, Tomimoto H, Takahashi R, Tashiro K, Ikegawa M, Kondo T. Proteomic pattern analysis discriminates among multiple sclerosis-related disorders.

Ann Neurol.2012;71(5)614-23.

Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.

Acta Neuropathol.2012;123(3):381-394.

Otsuka Y, Yamauchi H, Sawamoto N, Iseki K, Tomimoto H, Fukuyama H. Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis.

AJNR Am J Neuroradiol.2012;33(4):726-32.

Lu MH, Takemoto M, Watanabe K, Luo H, Nishimura M, Yano M, Tomimoto H, Okazaki T, Oike Y, Song WJ. Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice.

J Physiol. 2012;15:590(Pt 16):4029-44.

Takata K, Takada T, Ito A, Asai M, Tawa M, Saito Y, Ashihara E, Tomimoto H, Kitamura Y, Shimohama S. Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease.

Int J Alzheimers Dis. 2012;2012:685739.

Fujita Y, Kuchimaru T, Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R. In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe.

PLoS One. 2012;7(10):e48051.

Umino M, Maeda M, Matsushima N, Itoh A, TaniguchiA, Tomimoto H. Unusual MR feature presenting discrete involvement of pyramidal tract in progressive multifocal leukoencephalopathy: A case report.

Open Journal of Medical Imaging.2012; 2:100-102.

島田拓弥、佐々木良元、伊井裕一郎、谷口彰、上田有紀人、冨本 秀和. 舌咽,迷走神経障害をともなったChurg-Strauss症候群の1例.

臨床神経52:507-510, 2012

石川英洋, 牧 俊樹, 大達清美, 川田憲一, 冨本秀和. 無菌性髄膜炎様の症状で発症し,Protein S欠乏症による脳静脈血栓症と判明した1例.

臨床神経52:762-768,2012

坂井利行, 冨本秀和. 神経画像検査にて脳静脈還流異常をみとめた一過性全健忘の39歳女性例.

臨床神経52:769-773, 2012

谷口彰、佐々木良元、冨本秀和. 発症早期に髄膜脳炎を呈した成人発症Still病の1例.

神経治療学29(1):65-69, 2012

2011年

Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H. Astrocytic neuroprotection through induction of cytoprotective molecules; a proteomic analysis of mutant P301S tau-transgenic mouse.

Brain Res.2011;1410:12-23.

Satoh M, Nakase T, Nagata K, Tomimoto H. Musical anhedonia: Selective loss of emotional experience in listening to music.

Neurocase.2011;(5):410-417.

Satoh M, Narita M, Tomimoto H. Three cases of focal embouchure dystonia: classifications and successful therapy using a dental splint.

Eur Neurol. 2011;66(2):85-90.

Shindo A, Satoh M, Kajikawa H, Ito N, Miyamura H, Tomimoto H. Recurrent transient topographical amnesia: a patient with frequent episodes.

J Neurol.2011; 258(8):1566-1567.

Taniguchi A, Ii Y, Kobayashi H, Maeda M, Tomimoto H. Bilateral abducens nerve palsy by compression from bilateral anterior inferior cerebellar artery.

J Neurol.2011;258(12):2271-2273.

Tomimoto H. Subcortical vascular dementia.

Neurosci Res. 2011;71(3):193-199.

Ihara M, Tomimoto H. Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes.

Aging Res. 2011;2011:978761.

Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R. Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction.

Neuroreport. 2011;22(9):442-447.

Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H. Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice.

Stroke. 2011 ;42(4):1122-1128.

Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H. Watershed infarcts in a multiple microembolic model of monkey. Neurosci Lett.

Neurosci Lett. 2011;499(2):80-83.

Naito E, Matsumoto R, Hagura N, Oouchida Y, Tomimoto H, Hanakawa T. Importance of precentral motor regions in human kinesthesia: A single case study.

Neurocase.2011;17(2):133-147.

Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R. Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.

PLoS One. 2011;6(5):e20427.

Saito S, Ozaki A, Takahashi M, Ito H, Matsumoto S, Tomimoto H. A clustering of multifocal cerebral infarctions in CADASIL: A case report J

Neurol.2011;258(2):325-327.

Ueno M, Nakagawa T, Nagai Y, Nishi N, Kusaka T, Kanenishi K, Onodera M, Hosomi N, Huang CL, Yokomise H, Tomimoto H, Sakamoto H. The expression of CD36 in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.

Neuropathol Appl Neurobiol. 2011;37(7)727-737.

Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R. The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.

PLoS One. 2011;6(1):e16567.

Yang R, Zhou R, Chen L, Cai W, Tomimoto H, Sokabe M, Chen L. Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation.

Neuropharmacology.2011;60(2-3):529-541.

冨本秀和. 皮質下血管性認知症;認知症疾患における位置づけ.

臨床神経51:940-942, 2011

2010年

Taniguchi A, Kuzuhara S, Tomimoto H. Painful neck on rotation; diagnostic significance for crowned dens syndrome.

J Neurol.2010;257(1):132-135.

Okamoto Y, Ihara M, Tomimoto H. Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy.

Neurology.2010;74(1):93.

Nishio K, Ihara M, Yamasaki N, Kalaria RN, Makia T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H. A mouse model characterizing features of vascular dementia with hippocampal atrophy.

Stroke.2010;41(6):1278-1284.

Ueno M, Onodera M, Naya T, Toyama Y, Hosomi N, Huang C-L, Nishiyama Y, Kusaka T, Miki Y, Kohno M, Tomimoto H, Sakamoto H. Axonal damage in acute cerebral infarction showing ADC reduction.

J Neurol.2010;257(9):1559-1561.

Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R. Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion.

Stroke.2010;41(8):1798-1806.

Iseki K, Hanakawa T, Hashikawa K, Tomimoto H, Nankaku M, Yamauchi H, Hallett M, Fukuyama H. Gait disturbance associated with white matter changes: a gait analysis and blood flow study.

Neuroimage.2010;15;49(2):1659-1666.

Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T,Shimohama S, Shimohama S. Galantamine-induced amyloid-beta clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.

J Biol Chem.2010;285(51):40180-40191.

松尾皇、小久保康昌、藤枝淳史、冨本秀和. 悪性リンパ腫と重症筋無力症.

神経内科 73(1) 60-69, 2010

町野由佳、中山茂穂、高島慎吾、冨本秀和. てんかん発作をくりかえした脳表ヘモジデリン沈着症の1例.

臨床神経50:108-110, 2010

内藤寛、朝日理、冨本秀和. 痙性対麻痺におけるbacrofen持続髄注療法.

神経治療学 27(5): 689-695, 2010

坂井利行、近藤昌秀、冨本秀和. 発作の誘因としてValsarva負荷の関与が疑われた一過性全健忘の3症例;高磁場 脳MRIを用いた検討.

臨床神経50(7):473-477,2010

冨本秀和.皮質下血管性認知症の診断と治療

臨床神経50(8):539-546,2010

2009年

Tomimoto H. Comments on 'Subinsular vascular lesions: an analysis of 119 consecutive autopsied brains'- author's reply.

Eur J Neurol.2009 Jan;16(1):e5.

Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, Nishi E. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.

Nat Neurosci. 2009;12(12):1506-1513.

Tomimoto H. Comments on 'Subinsular vascular lesions: an analysis of 119 consecutive autopsied brains'- author's reply.

Eur J Neurol.2009 Jan;16(1):e5.

Okamoto Y, Ihara M, Fujita Y, Ito H, Takahashi R, Tomimoto H. Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia.

Neuroreport.2009;20(11):990-996.

Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, Takahashi R. Autoimmune autonomic ganglionopathy with Sjögren's syndrome: significance of ganglionic acetylcholine receptor antibody and therapeutic approach.

Auton Neurosci.2009;146(1-2):33-35.

Takata K, Kitamura Y, Nakata Y, Matsuoka Y, Tomimoto H, Taniguchi T, Shimohama S. Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease.

Am J Pathol.2009;175(1):17-24.

Kubo K, Nakao S, Jomura S, Sakamoto S, Miyamoto E, Xu Y, Tomimoto H, Inada T, Shingu K. Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats.

Brain Res.2009;1279:139-46.

Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-UtsugiM, Kinoshita A, Takahashi R. Chronic cerebral hypoperfusion accelerates amyloidβ deposition in APPSwInd transgenic mice.

Brain Res. 2009;1294:202-210.

Kobayashi K, Okamoto Y, Inoue H, Usui T, Ihara M, Kawamata J, Miki Y, Mimori T, Tomimoto H, Takahashi R. Leukoencephalopathy with cognitive impairment following tocilizumab for the treatment of rheumatoid arthritis (RA).

Intern Med.2009;48(15):1307-1309.

2008年

Shibata M, Yamasaki N, Miyakawa T, Ohtani R, Ihara M, Takahashi R, Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion.

Stroke.2008;38:2826-2832.

Fujita Y, Lin JX, Takahashi R, Tomimoto H. Cilostazol alleviates cerebral small-vessel pathology and white-matter lesions in stroke-prone spontaneously hypertensive rats.

Brain Res.2008;1203:170-176.

Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R. Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.

J Neuropathol Exp Neurol. 2008;67:984-993.


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若手医師研究実績
後期研修のご案内
認知症センター
「遺伝性脳小血管病CADASILのデータベース構築と運用」研究班
「神経難病のレスパイト入院に関する実態調査」について
既存試料使用に対する配慮に対して
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