遺伝子機能の，その先へ
担当：成瀬 智恵 准教授
糖鎖合成酵素に着目し、IgA腎症や造血幹細胞生着不全への影響について研究を進めています。
IKZF3/ZFP91キメラとサリドマイド類似物質を用いたSuper Degronシステムを活用し、 マウス生体において特定の標的タンパク質を迅速かつ特異的に分解・制御する技術の応用を行っています。
Naruse C, et al. "Differential substrate degradation by super-degron: EGFP in wild-type mouse cells, PD-1 requires CRBN humanization." iScience.
Pan X, et al. "Critical role of the potential 𝘖-linked glycosylation sites of CXCR4 in cell migration and bone marrow homing of hematopoietic stem progenitor cells." Stem Cells.
Hen W, et al. "Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice." Front Immunol.
Naruse C, et al. "A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice." NAR Cancer.
Li M, et al. "Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome." Nature Communications.
Naruse C, et al. "Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes." FASEB Journal.
Takagaki S, et al. "Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow." Scientific Reports.