Institute of Medical Life Science

Clinical Medical Sciences

Department Cardiology and Nephrology
Staff Masaaki ITO, MD, PhD, Professor
Norikazu YAMADA, MD, PhD, Associate Professor
Eitaro FUJII, MD, PhD, Lecturer
Kaoru DOHI, MD, PhD, Lecturer
Research Interests Both clinical and basic researches in the cardiovascular and renal fields are now currently carried. The projects in the Department of Cardiology and Nephrology are as follow:
(1) Clinical research in hemodynamics and neurohormonal regulation in patients with heart failure and/or cardiomyopathy.
(2) A thorough assessment of myocardial structure, function and perfusion by cardiac echo, CT and magnetic resonance imaging.
(3) Clinical research for risk assessment including hypertension, dyslipidemia, sleep apnea, diabetes and anemia for the prevention of atherosclerotic diseases and heart failure.
(4) Clinical research about outcome after revascularization against coronary and peripheral arterial diseases, and development of new cardiac catheterization therapies.
(5) Clinical research evaluating the effects of exercise training and DPP-4 inhibitors on exercise capacity and cardiovascular function in diabetic patients with myocardial infraction.
(6) The cohort study about the onset and management of myocardial infarction in Mie prefecture (MIE-ACS study).
(7) Molecular biology and pharmacology-based research in cardiovascular system and diseases, especially the researches for the regulation of vascular tone including systemic and pulmonary hypertension, and heart failure.
(8) Molecular research in cardiac hypertrophy and cardiomyopathy using genetically engineered mouse models and human iPS cells.
(9) Clinical research in electrophysiology including investigation of mechanisms of cardiac arrhythmias and developing new treatment approaches to tachyarrhythmias with drugs, electrical devices, catheter ablation.
(10) Clinical research in mechanism, diagnosis and treatment of pulmonary hypertension, pulmonary thromboembolism and deep vein thrombosis, and prevention of venous thromboembolism.
(11) Study of pathogenesis, treatment and prevention of progressive renal disease, such as immunoglobulin A nephropathy, diabetic nephropathy and nephrosclerosis.
(12) Study of genetic predisposing factors in chronic progressive renal disease.
(13) Clarification of the mechanism that accelerates aging in patients with chronic renal failure.
(14) Study of the osteoimmunology in hyperparathyroidism.
(15) Development of a new blood purification column.
(16) Development of new treatment for glomerulopathy by blood purification therapy.
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Department Hematology and Oncology
Staff Naoyuki Katayama , MD, PhD, Professor
Masahiro Masuya, MD, PhD, Associate Professor
Motoko Yamaguchi, MD, PhD, Assistant Professor
Toshirou Mizuno, MD, PhD, Assistant Professor
Research Interests The following investigations about hematological disorders and solid tumors are currently carried out to clarify their pathogenesis and develop new treatments.
(1) Investigation of the mechanism of human hematolymphopoiesis for cell therapy and regenerative medicine and for understanding of hematopoietic disorders, using newly-established coculture system.
(2) Elucidation of pathogenic mechanism in the development of inflammation, including graft versus host disease and organ fibrosis, and cancer through the analysis of the association of hematopoietic cells and factors in the microenvironment, such as chemokine and extracellular matrix.
(3) Analysis of clinicopathological features, immunophenotype, and gene expression profile of lymphomas
(4) Analysis of valuable predictive factors of response to drug therapy and those for prognosis in patients with solid tumors
(5) Clinical trials for hematopoietic disorders and solid tumors
(6) Clinical research about assessment and countermeasure to the adverse events associated with chemotherapy such as febrile neutropenia
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Department Gastroenterology and Hepatology
Staff Yoshiyuki TAKEI, MD, PhD, Professor
Motoh IWASA, MD, PhD, Associate Professor
Noriyuki HORIKI, PhD, Associate Professor
Hiroshi HASEGAWA, MD, PhD, Assistant Professor
Norihiko YAMAMOTO, MD, PhD, Assistant Professor
Research Interests We focus on the translational research (clinic to bench or bench to clinic) including liver, gut, gall bladder, pancreas, and organ-organ communication.
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Department Pulmonary and Critical Care Medicine
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Department Diabetes, Metabolism and Endocrinology
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Department Neurology
Staff Hidekazu TOMIMOTO, MD, PhD, Professor
Akira TANIGUCHI, MD, Lecturer
Keita MATSUURA, MD, PhD, Lecturer
Research Interests We are studying stroke and dementia, especially of vascular type,
focusing on
(1)Treatment and prevention of stroke
(2)Pathogenesis of vascular dementia and cerebral small vessel disease
In clinical setting, we are studying diagnosis and treatment of all type of ischemic stroke with the use of neuroradiological, physiological and immunochemical methodologies. Regarding on dementia, we have established animal model of vascular dementia, ie. a mouse model of chronic cerebral hypoperfusion, and are searching for the pathogenesis of vascular dementia. Indeed, we have succeeded to detect cortical microinfarcts on ultrahigh-field MRI, which should be a powerful tool for diagnosing cerebral amyloid angiopathy. Our research goal is early detection and prevention of stroke and dementia.
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Department Family Medicine and Community Medicine
Staff Yousuke TAKEMURA, MD, PhD, Professor
Hideki WAKABAYASHI, MD, PhD, MA, Lecturer
Tomohiro TAGUCHI, MD, Assistant Professor
Masaru KITAMURA, MD, Assistant Professor
Yohei Mori, MD, Assistant Professor
Shuhei ICHIKAWA, MInf, Assistant Professor
Satoshi Kondo, MD, Assistant Professor
Michiko Goto, PhD, Assistant Professor
Research Interests Our department is investigating several themes in family medicine, general practice, community medicine, and medical education. We especially focus on the behavioral aspects of patients and medical professionals. We use both quantitative and qualitative methods.
(1) Relationship between the basis of the family medicine and health outcome.
(2) To establish the method to build better team in medical setting
(3) Collaboration between primary care physician and occupational physician
(4) Cost-effectiveness of the home care
(5) Professionalism in physicians
(6) Science communication in medical setting
(7) Efficacy of the longitudinal clinical clerkship in local community
(8) Interprofessional education for students in medical school
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Department Neuropsychiatry
Staff Motohiro OKADA, MD, PhD, Professor
Hisashi TANII, MD, PhD, Associate Professor
Takashi SHIROYAMA, MD, PhD, Lecturer
Eishi MOTOMURA, MD, PhD, Lecturer
Research Interests To develop novel medications against psychiatric disorders and neurological disease, i.e. schizophrenia, bipolar disorder, anxiety disorder, autoimmune psychotic disease, epilepsy and Parkinson’s disease, we clarify the pathogenesis and pathophysiology of neuropsychiatric dysfunctions using neuro-psychological neuro-psycho-physiological, molecular biological clinical studies with neuro-psycho-pharmacological basic studies.
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Department Pediatrics
Staff Masahiro Hirayama M.D., Ph.D.
Yoshihide Mitani M.D., Ph.D.
Shotaro Iwamoto M.D., Ph.D.
Hidemi Toyoda M.D., Ph.D.
Hirofumi Sawada M.D., Ph.D.
Research Interests We are studying physiological and molecular mechanisms on
1) Pediatric malignant diseases
2) Hematopoietic stem cell transplantation
3) Pediatric congenital heart diseases, pulmonary hypertension, and Kawasaki disease
4) Pediatric neuromuscular diseases
Moreover, our lab is the central laboratory of Japan Children's Cancer Group (JCCG) for minimal residual disease. Our research goals are to investigate the mechanism of childhood cancers, heart diseases, and neuromuscular diseases and to cure the sick children.
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Department Dermatology
Staff Keiichi YAMANAKA, MD, PhD, Professor
Koji HABE, MD, PhD, Associate Professor
Hiroshi KITAGAWA, MD, PhD, Assistant Professor
Makoto KONDO, MD, PhD, Assistant Professor
Research Interests We are focusing on molecular and histopathological analysis, molecular diagnosis and development of new therapies for resistant skin diseases, including atopic dermatitis, psoriasis, cancer, and infectious diseases. We are currently performing several experiments as a group consisting with two instructors and four graduate students. Following issues are currently investigated;
1) Molecular analysis for skin diseases.
Skin disorders affect to systemic inflammation including abdominal aortic remodeling and systemic amyloidosis. We are trying to find the new evidence and therapies for these complications. Main focus: atopic dermatitis, psoriasis, and skin cancer.
2) The development of new drugs for skin neoplastic diseases.
New therapies will be required to overcome resistant cancer.
3) Mouse skin disease models by gene manipulation.
Main focus: atopic dermatitis mouse models
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Department Radiology
Staff Hajime Sakuma, MD, PhD, Professor
Yasutaka Ichikawa, MD, PhD, Associate Professor
Masaki Ishida, MD, PhD, Associate Professor
Motonori Nagata, MD, PhD, Lecturer
Akinori Takada, MD, PhD, Lecturer
Research Interests Our research areas include advanced diagnostic imaging using 3T MRI and dual-source CT, nuclear medicine employing advanced PET-CT with cyclotron, vascular and nonvascular interventional radiology (IVR), and radiation oncology. We are holding the leading positions in international societies as well as in Japan in the following research fields of Radiology.
(1) Cardiac MRI and CT, Coronary MR angiography and myocardial perfusion imaging
(2) Vascular IVR, Aortic stent grafting
(3) Non-Vascular IVR, Radiofrequency ablation and cryotherapy
(4) Radiation oncology
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Department Molecular and Laboratory Medicine
Staff Hideo WADA, MD, PhD, Associate Professor
Naoki FUJIMOTO, MD, PhD, Lecturer
Research Interests We are studying and developing laboratory techniques to analyze the pathophysiology and molecular mechanisms of various diseases and to diagnose, monitor and predict these diseases.
1) Diagnosis, monitoring and treating disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP) and venous thromboembolism (VTE)
2) Diagnosis of thrombophilia and hemophilia by molecular biology
3) Monitoring antithrombotic therapy
4) Developing biomarkers for the evaluation of a hypercoagulable state
5) Prophylaxis for thrombosis and bleeding
6) Developing heart function tests and evaluating the results
7) Monitoring heart failure patients
8) Evaluating the risk factors for cardiovascular diseases
9) Diagnosing thrombosis based on imaging findings
10) Evaluating cardiac arrhythmia
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Department Clinical Pharmaceutics
Staff Takuya IWAMOTO, PhD, Professor
Hideo KATO, PhD, Associate Professor
Toshinori HIRAI, PhD, Lecturer
Research Interests For proper use of drugs and assurance of their efficacy and safety, we are studying basic and clinical research based on pharmacokinetics, cellular biology and epidemiology listed as follows.
1) Monitoring of drug blood concentration and accomplishment of optimal dosage regimen
2) Molecular mechanisms and clinical application of drug metabolizing enzymes and transporters
3) Exploration of factors and biomarkers associated with efficacy and side effects of drugs
4) Optimal dosage adjustment based on pharmacokinetics / pharmacodynamics (PK/PD) theory
5) Role and activity of clinical pharmacists in multidisciplinary team care
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Department Hepatobiliary Pancreatic and Transplant Surgery
Staff Shuji Isaji, MD, PhD:Professor and Chairman
Hiroyuki Sakurai, MD, PhD:Associate Professor
Masanobu Usui, MD, PhD:Associate Professor
Shugo Mizuno, MD, PhD:Assistant Professor
Masashi Kisiwada, MD, PhD: Assistant Professor
Yoshinori Azumi, MD, PhD: Assistant Professor
Naohisa Kuriyama, MD, PhD: Assistant Professor
Research Interests We are studying basic and clinical research related with hepatobiliary pancreatic and transplant surgery
(1) Liver transplant surgery: ischemic re-perfusion injury in rat model, influence of genotype on the pharmacokinetics of tacrolimus in LT patients
(2) Biliary surgery: effectiveness of preoperative chemotherapy for perihilar carcinoma, prognostic factors of biliary cancers (tumor budding, epithelial mesenchymal transition: EMT)
(3) Pancreatic surgery: effectiveness of preoperative chemoradiotherapy for pancreatic ductal adenocarcinoma, relationship between remnant pancreatic volume and its functions after pancreatectomy, Exploration of the effect of chemoradiotherapy on the expression of cancer associated extracellular matrix in locally advanced pancreatic cancer
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Department Gastrointestinal and Pediatric Surgery
Staff Masato KUSUNOKI, MD, PhD, Professor
Yasuhiko MOHRI, MD, PhD, Associate Professor
Yasuhiro INOUE, MD, PhD, Associate Professor
Toshimitsu ARAKI, MD, PhD, Associate Professor
Yuji TOIYAMA ,MD, PhD, Associate Professor
Research Interests Our department (gastrointestinal surgery) in Mie university has a broad research focus on understanding the molecular pathogenesis of human gastrointestinal cancer and inflammatory bowel disease. More specifically, the major objective of our research involves deciphering the interplay between genetic and epigenetic alterations in sporadic and familial forms colorectal cancer, colitis associated cancer and other gastrointestinal cancers (gastric and esophageal).
The broad mission of the research program is to:
Conduct high quality research into the pathogenesis of gastrointestinal cancers, inflammatory bowel disease and pediatric disease including malignancies.
Develop clinically useful biomarkers for the early detection of gastrointestinal cancers.
Develop clinically useful biomarkers that can help direct therapeutic treatments for patients with gastrointestinal cancers.
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Department Thoracic and Cardiovascular Surgery
Staff Motoshi TAKAO, MD, PhD, Professor
Yu SHOMURA, MD, PhD, Associate Professor
Akira SHIMAMOTO, MD, PhD, Associate Professor
Koji KAWAGUCHI, MD, PhD, Associate Professor
Hisato ITO, MD, PhD, Assistant Professor
Kentaro UMEZU, MD, PhD, Assistant Professor
Research Interests Cardiopulmonary transplantation, elucidation of the mechanism of organ damage and development of therapeutic methods
Exploratory study on the role of tumor immunity mediated by innate lymphocytes in interstitial pneumonia and lung cancer
Cardiopulmonary assisted circulation
Study on left ventricular afterload impedance and improvement of left ventricular remodeling after aortic valve stenosis surgery
Development of surgical prosthetic materials using autologous tissue
Evaluation of chronic effects of hemodynamic changes caused by Fontan surgery using liver hardness as an index
Clinical application of machine learning (artificial intelligence: AI)
Clinical application of 3D printing and 3DCG
Development of clinical devices for navigation surgery
Minimally invasive surgery /Robotic surgery :Education, training & clinical researchi
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Department Breast Surgery
Staff Tomoko OGAWA, MD, PhD, Professor
Makoto ISHITOBI, MD, PhD, Associate Professor
Research Interests Current Research
(1) Development of diagnostic imaging system for early stage breast cancer detect
(2) Development of a new method of image-guided biopsy for the diagnosis of minimal breast cancer
(3) Development and fundamental study of a new procedure of sentinel lymph node biopsy
(4) Development of a new procedure of oncoplastic surgery
(5) Fundamental study on tailor-made treatment for breast cancer: Relationship between gene-expression pattern and treatment outcome, and investigation of a new biomarker
(6) Fundamental study on carcinogenesis and metastasis of breast cancer
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Department Obstetrics and Gynecology
Staff Tomoaki Ikeda, MD, PhD, Professor and Chairman
Tsutomu Tabata, MD, PhD, Associate Professor
Toshiharu Okugawa, MD, PhD, Lecturer
Research Interests Research Content: Research content covers clinical and basic research which has been carried out in reproductive medicine, prenatal medicine and female genital malignancy.
(1)Elucidation of the cervical cancer carcinogenesis mechanism with research focused on inflammatory carcinogenesis by HPV.
(2)Clinical and basic research on the immunotherapy of ovarian cancer.
(3)Clinical research on ovarian cancer chemotherapy.
(4)A basic study on fertilization and implantation mechanisms.
(5)Study of lifestyle-related diseases pathogenesis after growth in intrauterine growth retardation children.
(6)Basic and clinical study of perinatal brain damage.
(7)Basic and clinical research on prevention and cause of death investigation of maternal mortality.
(8)Basic and clinical studies on diabetes mellitus pregnancy.
(9)Cardiotocography, basic and clinical research.
Guidance Content:
Training and guidance covers the research described above as well as biochemical, immunohistochemical analysis, gene analysis method, and pathological diagnosis. Clinical research covers analysis methods and implementation of clinical trials.
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Department Neurosurgery
Staff Hidenori SUZUKI, MD, PhD, Professor and Chairman
Toshio MATSUBARA, MD, PhD, Associate Professor
Masaki MIZUNO, MD, PhD, Associate Professor
Naoki TOMA, MD, PhD, Associate Professor
Research Interests Our program includes the clinical and basic science research for developing new techniques for diagnosis and treatment of neurosurgical diseases, such as vascular lesions, malignant and benign tumors, traumas, infections, malformations and functional diseases of the central nervous system.
Main Projects:
1) Molecular mechanisms of early brain injury and cerebral vasospasm after subarachnoid hemorrhage.
2) Development of devices for neuro-endovascular therapy.
3) Neuro-endovascular therapy for stroke and related diseases.
4) Computational flow dynamics (CFD) analysis of cerebral aneurysms concerning the growing and rupture risks.
5) Molecular mechanisms of epileptogenesis.
6) Development of new devices and techniques for spinal and peripheral nerve surgery.
7) Diagnostic imaging and multimodality therapy for malignant brain tumors.
8) Neuroendoscopic treatment of pituitary tumors and hydrocephalus.
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Department Orthopaedic Surgery
Staff Akihiro Sudo, MD, PhD, Professor
Masahiro Hasegawa, MD, PhD, Associate Professor
Hiroki Wakabayashi, MD, PhD
Koji Akeda, MD, PhD
Research Interests The Department of Orthopaedic Surgery, Mie University was established in 1951. We have mainly 6 divisions, and current clinical activities are focused on hip and knee joint surgeries, musculoskeletal tumor surgeries, spine surgeries, hand surgeries, rheumatoid arthritis, sport medicine, and bone metabolism.
Our department is also studying basic and clinical orthopaedic research focused on;
(1) Total hip and knee arthroplasties
(2) Musculoskeletal sarcomas and bone metastasis
(3) Microsurgery
(4) Osteoporosis
(5) Spinal Instrumentation
During these research fields, biomolecular and biomechanical engineering, 3D computer modeling, molecular imaging, in vivo and in vitro studies have been researched, and then these studies and surgical expertise coalesce to foster improved patient outcomes.
Our Orthopaedic Department upholds tradition by seeking answers and resolutions that will impact the diagnosis, treatment, and quality of life for orthopaedic and cancer patients.
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Department Nephro-Urologic Surgery and Andrology
Staff Takahiro Inoue, MD, PhD, Professor
Hideki Kanda, MD, PhD, Associate Professor (Lecturer)
Research Interests We are now engaging the following projects:
(1) Tissue remodeling in pathological conditions including benign hypertrophy (BPH) and cancer of prostate gland
(2) Stromal-epithelial interaction in normal and abnormal disease (cancer) of urogenital organ (prostate, bladder, kidney)
(3) Patient-derived xenograft models as a research in urological malignancies
(4) Evaluation of urinary phospholipids for biomarker of prostate cancer diagnosis and treatments
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Department Ophthalmology
Staff Mineo KONDO, MD, PhD, Professor
Kengo IKESUGI, MD, PhD, Associate Professor
Masahiko SUGIMOTO, MD, PhD, Associate Professor
Hisashi MATSUBARA, MD, PhD, Associate Professor
Research Interests Using electroretinogram (ERG) for the diagnosis of various retinal diseases – Prof. Kondo
Animal models of human retinal and optic nerve diseases analysed using ERG – Prof. Kondo
Glaucoma research(epidemiology, new class of drugs, surgery) – Dr. Ikesugi
Diabetic retinopathy research – Dr. Sugimoto
Ocular neovascularization regulated by extracellular matrix – Dr. Sugimoto
Treatments for age-related macular degeneration – Dr. Matsubara

In addition, almost all fields of clinical ophthalmology (e.g. corneal transplant, lacrimal passage, tear dynamics, pediatric ophthalmology, neuro-ophthalmology and low vision) will be considered as the subject of research, playing a role of the only university hospital in Mie Prefecture.
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Department Otorhinolaryngology-Head and Neck Surgery
Staff Kazuhiko TAKEUCHI, MD, PhD, Professor and Chairman
Masayoshi KOBAYASHI, MD, PhD, Associate Professor
Hajime ISHINAGA, MD, PhD, Assistant Professor
Research Interests The main interests of our department are defense mechanism of upper and lower airways in the normal and diseased states. The following subjects have been extensively studied.
1) Molecular mechanisms of airway mucus hypersecretion
Mucin gene expression and the effect of various drugs on the expression is examined using reporter gene assays.
2) Pathophysiology and treatment of allergic rhinitis
3) Primary ciliary dyskinesia
Electronmicroscopic studies of motile cilia and mutation analysis in the genes associated with ciliary movement are carried out in collaboration with affiliated facilities.
4) Pathophysiology and treatment of smell and taste disorders
5) Role of microRNAs in the development of head and neck carcinoma
6) Improvement of neural regeneration after olfactory system injury
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Department Plastic and Reconstructive Surgery
Staff Mitsunaga Narushima
Research Interests Our clinical research focuses on developing new diagnostic and therapeutic techniques for the management of lymphedema and other vascular malformations while our basic science research is focused on neurovascular repair and regeneration using squid, newt and mouse models. Newts have the extraordinary ability to regenerate multiple body parts and organs without any scarring following injury through nerve dependent epimorphic regeneration. This makes them valuable models in plastic surgery research for understanding the physiological and molecular mechanisms of regeneration.
We are currently studying neurovascular repair by supermicrosurgical anastomosis and optimized axonal fusion techniques for immediate restoration of nerve function and prevention of Wallerian degeneration.
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Department Oral and Maxillofacial Surgery
Staff Naoya ARAI, DDS, PhD, Professor
Kazuto KUROHARA, DDS, PhD, Associate Professor
Taku MURATA, DDS, PhD, Lecturer
Kasumi SHIMIZU, DDS, PhD, Lecturer
Research Interests Our goal is to take innovation from diagnosis to therapy of oral maxillofacial diseases. We have research projects blow:

# Mechanism of medication related osteonecrosis of the jaw (MRONJ)
# Regeneration and cure of alveolar and jaw bone
# Biocompatibility of titanium materials for alveolar and jaw
# Pilot study for molecular target drug of phosphodiesterase inhibitor for oral malignant tumor
# Signal transduction in oral cancer cells
# Clinical and statistical study of oral maxillofacial trauma
# Clinical and statistical study of maxillary impacted supernumerary teeth
# Oral cooling method for prevention of oral mucositis during chemotherapy
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Department Anesthesiology and Critical Care Medicine
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Department Clinical Anesthesiology
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Department Emergency and Critical Care Medicine
Staff Hiroshi IMAI, MD, PhD, Professor
Taichi TAKEDA, MD, PhD, Associate professor
Masaki FUJIOKA, MD, PhD, Instructor
Tsuyoshi HATADA, MD, PhD, Instructor
Research Interests Introduction
The Emergency and Critical Care Center at our facility supports emergency medicine in Mie Prefecture by providing intensive care at stages from pre-hospital care to tertiary emergency care.
Our mission is to educate and train substantial numbers of emergency and intensive care physicians in Mie Prefecture.

Research areas
We plan and implement research in areas including:
1) Basic research and clinical application concerning blood coagulation and cellular adhesion in sepsis.
2) Research into ARDS-related respiratory therapies using mechanical ventilation, PCPS/ECMO, EIT (electrical impedance tomography), and other modalities.
3) Research into treatment for acute-phase DIC accompanying trauma or sepsis.
4) Research into therapeutic hypothermia for cerebrovascular damage after CPA and traumatic brain injury.
5) Research into prognostic factors in cardiopulmonary resuscitation.

We also participate actively in a variety of multicenter collaborative research projects, assisting efforts to improve the quality of emergency and intensive care in Japan and produce world-class data originating in Japan.
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Pathology and Clinical Research in Internal Medicine

Staff Kojiro TAKASE, MD, Professor
Research Interests Overweight and life-style disease are closely related with eradication of Helicobacter pylori (H.P), which influences gastrointestinal hormone and gut flora. We are researching the following for these morbidity analyses.
(1) Changes in plasma ghrelin and leptin levels before and after eradiation of H.P .
The purpose of this research is to predict the onset of life-style disease induced by the weight increase following to H.P eradication, and eventually to prevent the onset of such disease by effectively controlling body weight.
(2) Gut flora in healthy person and patient with colon disease (colon cancer or colon adenoma).
If the occurrence of present/future colon disease can be predicted by investigating gut flora, and if the prognosis can be changed by the condition of the gut flora, control of the gut flora can be target of the prevention of colon diseases and the method of medical treatment.
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Department Neonatology
Staff Masaru IDO, MD, PhD, Professor
Hastumi YAMAMOTO, MD, PhD, Professor
Shigeki TANAKA, MD, PhD, Associate Professor
Motoki BONNO, MD, PhD, Associate Professor
Research Interests The Department of Neonatology focuses on the developmental immunology, genetic disorders and cognitive and behavior developmental science in the field of neonatology.
In our research on psychological development, we take two factors into consideration to study children’s healthy development; one is immaturity in neonatal period that has influences on the psychomotor development of the babies, and the other is their social and economical environment that affects children’s development and the onset of their disease.
Major research projects in our laboratory are as follows.
1.Elucidation of immunological feature in premature and mature neonate.
2.Elucidation of the immunological regulation in fertilization.
3.Elucidation of the molecular mechanism of congenital anomalies.
4.Analysis of the mechanism of signal transduction.
5.Elucidation of the factors which have effects on cognitive and behavior development of children.
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Department Child Medical Health and Development
Staff Toshiaki Ihara, M.D., Ph.D. , Professor
Takao Fujisawa, M.D., Ph.D., Professor
Shigeru Suga, M.D., Ph.D. , Associate Professor
Research Interests This division covers comprehensive and interdisciplinary medicine for children in the life cycle. Since many diseases are not restricted to certain age ranges and recent evidence shows that even senile diseases such as chronic obstructive lung disease or some kind of cancer start during childhood, the research in this division is oriented towards understanding of the pathophysiology of the diseases of childhood and adulthood over the life cycle. We also focus on global health problem where interdisciplinary effort is essential.
(Main research areas)
1) Infectious diseases: host defense mechanisms, development of vaccines, epidemiology of infectious diseases
2) Allergy and immunology: molecular mechanism of allergic diseases, clinical and translational studies for treatment of asthma and other allergic diseases
3) Metabolic diseases: clinical study on diabetes and obesity
4) Neurology: pathophysiology of intractable CNS diseases
5) Global Health: global epidemiology of infectious diseases, WHO projects for child health in developing countries
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Department Stress Science
Staff Teruhisa KOMORI, MD, PhD, Professor
Kayoko URAKAWA, MD, PhD, Professor
Research Interests We are studying mental stress and its reduction. In particular, we are focusing on
(1) Examination of utility of various strategies including music and fragrance
(2) Relapse prevention of psychiatric illness, sanitary education, regional support program and reinstatement support
(3) Psychoneuroimmunological research.

The stress is involved in various unhealthiness and illness of mind and body. The stress situation is examined from a psychoneuroimmunological viewpoint. The application of sense is promising in stress reduction and we are examined the effects of music and fragrance. In addition, the approach from many fields including education and regional support is examined, and the development of those effective programs is planned. The purpose of our research is to search for methods of stress reduction, and to contribute to the improvement of health.
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Department Health Promotion and Disease Prevention
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Department Rehabilitation Medicine
Staff Ryo MOMOSAKI, MD, PhD, MPH, Professor
Research Interests We are studying the assessment of disabilities and appropriate rehabilitation interventions. We focus on acute rehabilitation, preoperative rehabilitation, swallowing rehabilitation, stimulation therapy, and nutritional and pharmacological management of patients in rehabilitation. We are also focusing on real world research and health service research regarding rehabilitation using medical big data.
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