Research

Departments

Institute of Medical Life Science

Community, Industry & Academic Research Alliances (Endowment Department)

Department Immuno-Gene Therapy
Staff Hiroshi SHIKU, MD, PhD, Professor
Shinichi KAGEYAMA, MD, PhD, Prpfessor
Takashi WATANABE, MD, PhD, Professor
Yoshihiro MIYAHARA, MD, PhD, Associate Professor
Naozumi HARADA, PhD, Assistant Professor
Naohiro SEO, PhD, Assistant Professor
Yasushi AKAHORI, PhD, Assistant Professor
Research Interests We are doing basic/translational and clinical research on cancer immunotherapy;
Our main studies are as follows;
(1) Clinical trials of adoptive TCR-T cell transfer targeting NY-ESO-1, MAGE-A4 and WT1 antigens (Phase 1).
(2) Clinical trials of CHP-NY-ESO-1 vaccine for post-surgical esophageal cancer patients (Phase 2) and CHP-NY-ESO-1 vaccine with MIS416 adjuvant for refractory bladder cancer and other cancer patients (Phase 1).
(3) Translational research of efficient cancer vaccine development using novel long peptide sequencing desigen
(4) Translational research of novel immunotherapy, TriCombo, for checkpoint inhibitor-resistant tumors
(5) Translational research of new CAR-T cell recognizing peptide/MHC complex, so that the CAR is able to recognize intra-cellular antigen.
(6) Basic research of T cell-derived exosomes and TCR identification that recognizes mutated tumor antigen
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Department Human Research Promotion and Drug Development
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Department Innovative Neuro-Intervention Radiology
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Department Systems Pharmacology
Staff Toshio Tanaka, MD, PhD, Professor
Research Interests The Systems Pharmacology of Mie University has particular strengths in the areas of zebrafish-based phenomics systems pharmacology on in vivo signaling mechanisms and gene expression as targets of drug action. Zebrafish-based drug discovery has become a potential strategy by its high throughput quantitative in vivo phenomics screening and has already succeeded in several examples of first-in–class or repositioning drug discovery. Systems pharmacology is defined to identify the gene network which are involved in determining the responsiveness and to distinguish responders and non-responders to a given drug. Genome sequensing, transcriptome, proteome and metabolome analysis are of particular significance in omics-based reverse systems pharmacology. We use multiomics analysis to identify and validate therapeutic target genes by studying change of gene expression in human cells and zebrafish model of various human diseases and find novel drug target candidates through our systems pharmacology strategy.
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Community- and Industry-based Innovative Research (Endowment Department)

Department Dementia Prevention and Therapeutics
Staff Professor: Hidekazu Tomimoto
Associate Professor: Masayuki Satoh
Research Interests Our department is the first one which specializes dementia research in national university. We perform not only medical research, but also arrangement of social systems which are indispensable for taking care of demented people at home. We investigate dementia, especially its vascular type, from the view-point of pathology, neuroanatomy, and neuropsychology.
We also carry out music therapy for demented people with collaboration of medical doctor and music therapist. Furthermore, we organize care conference on problematic cases of dementia, with the help of many clinic doctors, welfare professionals, and prefectural servants in order to build network for demented people. We believe that such multifaceted activities will be needed in Japan which is now becoming super-aging society.
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Department Cancer Vaccine
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Department Innovative Surgery and Surgical Techniques Development
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Department Orthopedics and Sports Medicine
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Department Spinal Surgery and Medical Engineering
Staff Yuichi KASAI, MD, PhD, Professor
Toshihiko SAKAKIBARA, MD, Assistant Professor
Research Interests We are doing as below.
1) Teaching various spinal surgeries
2) Studying chronic pain of musculoskeletal disorders
3) Researching spinal biomechanics
4) Making medical devices for commercialization
5) Supporting Myanmar spinal surgeries
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Department Clinical Cardiovascular Research
Staff Professor: Mashio Nakamura, MD, PhD
Professor: Masaaki Ito, MD, PhD
Research Interests The Department has conducted research on a wide variety of cardiovascular disease. Especially, we have carried on a collaborative clinical study with associated facilities for risk of CV disease (hypertension, dyslipidemia and impaired glucose tolerance) and venous thromboembolism.
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Department Hematological Malignancies
Staff Motoko YAMAGUCHI, MD, PhD, Professor
Kana MIYAZAKI, MD, PhD, Assistant Professor
Research Interests We are studying the clinical features and molecular mechanisms of rare and intractable subtypes of lymphoma and other lymphoid malignancies. Our research has contributed to the establishment of treatments for some lymphoma subtypes, including NK/T-cell lymphoma and CD5-positive diffuse large B-cell lymphoma. We are conducting clinical trials of promising treatment strategies for lymphoma subtypes and doing outcome studies to assess the feasibility of new treatments in clinical practice. Our research goal is to improve the prognosis of patients with lymphoma.
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Cancer Professional Training Foundation Promoting Plan

Department Radiation Oncology
Staff Yoshihito NOMOTO, MD, PhD, Professor
Research Interests We are studying radiation oncology with biological, physical and clinical approach to eradicate cancers. Our main study themes are as follows.
Stereotactic body radiation therapy is curative radiation treatment option for local malignancy, from primary tumors to metastatic disease. It is carried out with use of precise delivery and higher doses of external beam radiation per treatment. We are studying optimal radiation dose and dose distribution for a cure with few complications.
Brachytherapy is useful method for dose concentration to tumor, and it is enabled with IGBT (Image Guided Brachytherapy) in radiation planning, recently. We are studying optimal radiation dose for uterine cervical cancer applying IGRT using MR image-guided optimization. We have developed an applicator for intraluminal irradiation for chest X ray negative lung cancer. We are investigating optimal dose fractionation and dose distribution to eradicate tumor with minimal damage of bronchial wall.
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Course of Nursing

Fundamental Nursing

Department Nursing Education
Staff Tomoko HAYASHI,RN,PhD,Professor
Kazumi IMURA,RN,PhD,Associate Professor
Chuharu MIYATA, RN, PhD, Associate Professor
Research Interests

We are focusing the research on nursing education. It includes basic nursing education and continuing education as a system of lifelong education.

We develop curricula, programs, teaching and evaluation methods in nursing, and discuss the issues we face in nursing education. We are dedicated to the study of nurse-patient relationship, communication skills in nursing, the empathy and Emotional Intelligence (EI) of nurses and nursing students, nurse’s autonomy, and Interprofessional Education (IPE).

Our goal is to establish a trusting relationship between nurses and patients.
Associate professor Miyata has been studied focusing on the concept of Nursing Administration as a mechanism to support the role of nureses and its ability in the health, medical care, and welfare.
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Department Fundamental Clinical Nursing
Staff Masahiro Masuya, MD, PhD, Professor
Keiko FUKUROKU, RN, PHN, PhD, Associate Professor
Research Interests

Dr. Masuya has been studying the role of macrophages and fibrocytes in organ fibrosis and carcinogenesis using mouse model. Furthermore, he has been investigating the methods for solving asome problems during treatment in patients with hematological malignancies. Now, he is planning to analyse the facotors associated with dysgeusia after chemotherapy in myeloma patioents.


Keiko FUKUROKU, RN, PHN, PhD, Associate Professor
We are studying on the intervention with exercise and effective support by nurses for elderly with musculoskeletal ambulation disorder symptom complex (MADS). Especially our aim is to develop a suitable support program on exercise adherence in community-based approach by co-operation with orthopedic clinics. We are studying on the association between ADL and walking ability improved by our exercise-intervention for elder patients with locomotive syndrome.

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Clinical Nursing

Department Oncology Nursing
Staff Mayumi TUJIKAWA, RN, PHN, PhD, Professor
Miwa ARAKI-SAKAGUCHI, RN, PHN, PhD, Associate Professor
Research Interests

We are interested in cancer nursing relating to prevention, treatment, palliative care, end of life care, and bereavement care for the cancer patients and their families. Especially we focus on integrated whole person care.

1. Quality of life(QOL) including the existential aspect of cancer survivors.
2. Holistic cancer nursing using complementary alternative medicine to improve their QOL.
3. Spiritual needs and care of the person in the end of life and one’s family.
4. Bereavement experience of family members and the bereavement care for the family.

This course has been selected as one of promotion plan for the platform of human resource development for cancer in Japan. The program for Certified Nurse Specialists (CNS) has been cultivating in this plan.

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Department Adult Health Nursing
Staff Sachie TAKEUCHI, RN, PhD, Professor
Research Interests

We focus the theme in perioperative setting and critical & emergency care setting. In these settings, patients and their family members might be under crisis and nurses have important roles not only to support them but also to develop their resilience. Team of Adult Health Nursing investigate the following studies.


1. We search the mechanism and meaning of intervention to develop the strength for resilience.

2. We try to structure nursing care for them to make their experiences under crisis to develop to energy for lives.

3. We search the work climate and education to produce effective motivation of nurses in these settings.


We have a view to improve wisdom globally and locally, and to contribute develop perioperative and critical & emergency nursing in Mie Prefecture.

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Department Midwifery, Maternal and Newborn Nursing
Staff Yoko Asaka, RN, MW, PhD, Professor
Research Interests

We are studying women and maternal health, child care support based on reproductive health and rights.

Specifically, we will research on bioethics and women’s rights, mentality of infertile women, fetus diagnosis and reproductive technique, mother-infant interaction, and so on.

Our research aim to women’s health and QOL development, child health improvement.

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Department Child Health Nursing
Staff Mari Matsuoka, RN, PhD, Professor
Mayumi Murabata, RN, PhD, Associate Professor
Research Interests

At our laboratory, we aim to develop human resources with a good balance of practice and research; clinicians who can resolve questions in clinical practice through research and provide evidence-based care for children and their families. We are studying nursing for children who experience chronic disease or disabilities with the need for medical devices and their families. The major topics are as follows;

- Pediatric Palliative Care
- End-of-life care for children and their family
- End-of-Life discussion and shared decision-making
- Clinical care and long-term follow up for children and AYA with cancer
- Education system for pediatric nurses who are engaging in pediatric palliative care
- Care for children with chronic illness
- Prevention of Clostridium difficile infection in children
- Protective care for children and their families from infection

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Department Gerontological Nursing
Staff Tokiko ISOWA, RN, PhD, Professor
Mayuko HIRAMATSU, RN, PhD, Associate Professor
Research Interests

The department’s current studies are various issues on gerontological nursing and disaster nursing. 
The major topics are as follows;
1) Health promotion for elderly people in rural area
2) Disaster nurse’s role for elderly people and vulnerable populations
3) End-of-life care for elderly people with dementia
4) Psychoneuroimmunology on stress situation


In addition, we develop community activities focusing on health promotion for elderly people and vulnerable populations in underpopulated area as industry-government-academia research group. Our research goals are to establish more effective care systems for supporting the lives of elderly people.

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Community Health Nursing

Department Mental Health and Psychiatric Nusring
Staff Mika Kataoka, RN, PHN, PhD, Professor
Keiichiro KIRIYAMA, RN, PHN, Associate Professor
Research Interests I am focusing the research on psychiatric mental health nursing. It includes development of role and skills based on nursing theory by psychiatric nurses, mental health for workers on workplace, how to reduce stress of people, etc.
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Department Public Health Nursing
Staff Susumu TANIMURA, PhD, Professor
Ritsuko NISHIDE, RN, PHN, PhD, Professor
Mayumi MIZUTANI, RN, PHN, PhD, Associate professor
Research Interests We investigate community health problems based on epidemiology and statistics. We also discuss the strategies necessary to achieve effective, high quality nursing intervention for all individuals, family, groups, and organizations in the community in order to extend healthy life expectancy, as well as to facilitate health promotion in a long-term and global perspective. Our research particularly focuses on:

1) Health and lifestyle for community residents;
2) Appropriate medical human resource allocation using geospatial analysis;
3) Spatial epidemiology for contemporary public health issues;
4) Healthy lifestyle of children and parental activities of caregivers;
5) Health behaviors to prevent noncommunicable diseases;
6) Cooperation for developing community-based integrated care system.
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