私達は最近、新規の神経ペプチドの発見に成功しました(Neuroreport 2004)。そのペプチドはこれまで見られなかったまったく新しい機能を持っていると思われ現在解明中です。このペプチドをマンセリンと命名しました。
現在特許公開中です。
抗マンセリン抗体は市販もされています。
Manserin, a novel peptide from secretogranin II in the neuroendocrine system
Aika Yajima, Mariko Ikeda, Kaoru Miyazaki, Toru Maeshima, Naoko Narita,
Masaaki Narita
Neuroreport, 2004; 15: 1755-1759.
Recently identified a novel neuropeptide manserin colocalize with the TUNEL-positive
cells in the top villi of the rat duodenum
Aika Yajima, Naoko Narita, Masaaki Narita
Journal of Peptide Science, 14; 773-776: 2008
Immunohistochemical localization of manserin,
a novel neuropeptide derived from secretogranin II, in rat adrenal gland, and
its upregulation by physical stress
Naoki Kamada1,2,
Kaori Tano1, Akiko Oyabu1, Yoshio Imura1,
Naoko Narita3, Yasura Tashiro1, Atsuko Uchida1,
Yoshihiro Komada2, Masaaki Narita1
International
Journal of Peptide Research and Therapeutics, (2010) 16:55–61
Manserin, a secretogranin II-derived peptide, distributes in the rat endocrine pancreas colocalized with islet-cell specific manner Kaori Tano1,2, Akiko Oyabu1, Yasura Tashiro1, Naoki Kamada1, Naoko Narita3, Fumio Nasu2, Masaaki Narita1Histochemistry and Cell Biology, in press