Department of Oral and Maxillofacial Surgery
Mie University Graduate School of Medicine



  • Iwamoto T, Okamoto A, Ishinaga H, Shimizu K, Gayle AA, Arai N, Takeuchi K, Okuda M.
    A novel approach to predict cetuximab-induced hypersensitivity reaction: detection of drug-specific IgE on basophils.
    Cancer Med. 5: 1004-1012, 2016


  • Inoue S, Arai N, Tomihara K, Takashina M, Hattori Y, Noguchi M.
    Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells.
    Eur J Pharmacol. 761 : 44-54, 2015
  • Ahmad F, Murata T, Shimizu K, Degerman E, Maurice D, Manganiello V.
    Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets.
    Oral Dis. 21 : e20-e50, 2015


  • Tomihara K, Fuse H, Heshiki W, Takei R, Zhang B, Arai N, Nakamori K, Noguchi M.
    Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.
    Oral Oncol. 50 : 457-467, 2014
  • Hiramoto K, Murata T, Shimizu K, Morita H, Inui M, Manganiello VC, Tagawa T, Arai N.
    Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
    Cell Signal. 26 : 1807-1817, 2014


  • Noto Z, Yoshida T, Okabe M, Koike C, Fathy M, Tsuno H, Tomihara K, Arai N, Noguchi M, Nikaido T.
    CD44 and SSEA-4 positive cells in an oral cancer cell line HSC-4 possess cancer stem-like cell characteristics.
    Oral Oncol. 49 : 787-795, 2013
  • Arai N, Inoue S, Tomihara K, Tsuno H, Noguchi M.
    In vitro synergistic effects of zoledronic acid and calcium on viability of human epithelial cells.
    Oral Dis. 2013 Mar;19(2):200-5.
  • Morita H, Murata T, Shimizu K, Okumura K, Inui M, Tagawa T.
    Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.
    Oncol Rep. 29 : 1275-1284, 2013