三重大成田正明研究室ではラット脳より生理活性ペプチドの単離に成功し、世界初と確認しました(Neuroreport 2004)。そのペプチドはこれまで見られなかったまったく新しい機能を持っていると思われ現在解明中です。このペプチドをマンセリンと命名しました。
現在特許公開中です。
抗マンセリン抗体は市販もされています。
マンセリンは脳内の新物質のため、解析することが多く手が回っていません。
新物質であるマンセリン研究、一緒にやりませんか。
三重大Rナビにも特集されました。
- Manserin, a novel peptide from secretogranin II in the neuroendocrine system
Aika Yajima, Mariko Ikeda, Kaoru Miyazaki, Toru Maeshima, Naoko Narita, Masaaki Narita
Neuroreport, 2004; 15: 1755-1759.
- Recently identified a novel neuropeptide manserin colocalize with the TUNEL-positive cells in the top villi of the rat duodenum
Aika Yajima, Naoko Narita, Masaaki Narita
Journal of Peptide Science, 2008; 14: 773-776.
- Immunohistochemical localization of manserin, a novel neuropeptide derived from secretogranin II, in rat adrenal gland, and its upregulation by physical stress
Naoki Kamada, Kaori Tano, Akiko Oyabu, Yoshio Imura, Naoko Narita, Yasura Tashiro, Atsuko Uchida, Yoshihiro Komada, Masaaki Narita
International Journal of Peptide Research and Therapeutics, 2010; 16: 55-61.
- Manserin, a secretogranin II-derived peptide, distributes in the rat endocrine pancreas colocalized with islet-cell specific manner
Kaori Tano, Akiko Oyabu, Yasura Tashiro, Naoki Kamada, Naoko Narita, Fumio Nasu, Masaaki Narita
Histochemistry and Cell Biology, 2010; 134: 53-57.
- Secretogranin II and its derivative peptide, manserin, are differentially localized in Purkinje cells and unipolar brush cells in the rat cerebellum
Takeshi Ohkawara, Akiko Oyabu, Michiru Ida-Eto, Yasura Tashiro, Kaori Tano, Fumio Nasu, Naoko Narita, Masaaki Narita
International Journal of Peptide Research and Therapeutics, 2011; 17: 193.
- Existence of manserin, a secretogranin II-derived neuropeptide, in the rat inner ear: relevance to modulation of auditory and vestibular system
Michiru Ida-Eto, Akiko Oyabu, Takeshi Ohkawara, Yasura Tashiro, Naoko Narita, Masaaki Narita
Journal of Histochemistry and Cytochemistry, 2012; 60: 69-75.
- Subtype-specific parafollicular localization of the neuropeptide manserin in the rat thyroid gland
Takeshi Ohkawara, Akiko Oyabu, Michiru Ida-Eto, Yasura Tashiro, Naoko Narita, Masaaki Narita
Acta Histochemica, 2013; 115: 190-194.
- Localization of manserin, a secretogranin II-derived neuropeptide, in the oviduct of female rats
Michiru Ida-Eto, Makiko Nomura, Takeshi Ohkawara, Naoko Narita, Masaaki Narita
Acta Histochemica, 2014; 116: 522-526.
- Specific localization of manserin peptide in the rat carotid body
Michiru Ida-Eto, Takeshi Ohkawara, Masaaki Narita
Acta Histochemica, 2018; 120: 11-14.
- Localization of the neuropeptide manserin in rat dorsal root ganglia: Involvement in nociceptive function
Michiru Ida-Eto, Takeshi Ohkawara, Masaaki Narita
Acta Histochemica, 2021; 123: 151812.