ABOUT US
The activity of the proteins that cleverly regulate neurons is not simply turned on and off, but also exhibits spatiotemporal dynamics such as localization and timing at individual synapses. However, the physiological significance of these dynamics is largely unknown. In our group, we have developed a molecular manipulation technique, CALI (Chromophore-assisted light inactivation), to locally photoinactivate proteins. Our group is developing new memory research focusing on the spatio-temporal dynamics of molecular functions by using CALI (Chromophore-assisted light inactivation) and two-photon microscopy imaging. In addition, we are developing novel optical techniques that enable manipulative analysis of a wider variety of molecules, and approaching the unknown principles that link each level from molecules to behavioral expression, with the aim of creating a new discipline in brain science.