Takemoto Lab.

PUBLICATIONS

Original Paper

  1. Trusel M, Nuno-Perez A, Lecca S, Harada H, Lalive AL, Congiu M, Takemoto K, Takahashi T, Ferraguti F and Manuel M “Punishment-predictive cues guide avoidance through potentiation of hypothalamus-to-habenula synapses.“ Neuron 102(1):120-127, 2019 LINK
  2. Riani Y D, Matsuda T, Takemoto K, Nagai T. “Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation.” BMC Biol. 16(1):50, 2018
  3. Takemoto K* (*co-corresponding author), Iwanari H, Tada H, Suyama K, Sano A, Nagai T, Hamakubo T and Takahashi T* “Optical inactivation of synaptic AMPA receptors erases fear memory.” Nat. Biotechnol., 35(1):38-47, 2017 LINK
  4. Tada H, Miyazaki T, Takemoto K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Taguchi A, Kawai H, Komiya K, Suyama K, Abe H, Sano A and Takahashi T “Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex.” Sci. Rep. 7(1):8471, 2017
  5. Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Komiya K, Suyama K, Sano A, Taguchi A and Takahashi T “Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.” Proc Natl Acad Sci U S A., 113(45), E7097-E7105, 2016
  6. Sakamaki K, Ishii TM, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita A, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung SK, Matsuoka S, Koyamada K, Sawasaki T, Nagai T and Ueno N “Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.” Biochem Biophys Acta., 1863(11):2766-2783, 2016
  7. Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi-Jitsuki A, Takahashi T, Nogo receptor signaling restricts adult neural plasticity by limiting synaptic AMPA receptor delivery., Cereb. Cortex, 26, 427-439, 2016
  8. Liu T, Yamaguchi Y, Shirasaki Y, ShikadaK, Yamagishi M, Hoshino K, Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O and Miura M “Single-cell imaging of caspase-1 dynamics reveals all-or-none response of inflammasome signaling.” Cell Rep. 8(4):974-982, 2014
  9. Takemoto K, Matsuda T, Sakai N, Fu D, Noda M, Uchiyama S, Kotera I, Arai Y, Horiuchi M, Fukui K, Ayabe T, Inagaki F, Suzuki H and Nagai T. “SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation.” Sci.Rep. 3, 2629, 2013 LINK
  10. Ohtsuka K, Sato S, Sato Y, Sota K, Ohzawa S, Matsuda T, Takemoto K, Takamune N, Juskowiak B, Nagai T and Takenaka S　“Fluorescence imaging of potassium ions in living cells using a fluorescent probe based on a thrombin binding aptamer-peptide conjugate.” Chem Commun., 48, 4740–4742, 2012
  11. Yamaguchi Y, Shinotsuka N, Nonomura K, Takemoto K, Kuida K, Yoshida H and Miura M.　“Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.“ J.Cell.Biol. 195(6): 1047-1060, 2011
  12. Takemoto K, Matsuda T, McDougall M, Klaubert D, Hasegawa A, Los G, Wood K, Miyawaki A and Nagai T “Chromophore-assisted light inactivation of HaloTag fusion proteins labeled with eosin in living cells.” ACS Chem. Biol. 6(5):401-406, 2011 LINK
  13. Kuranaga E, Matsunuma T, Kanuka H, Takemoto K, Koto A, Kimura K and Miura M　“Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia.” Development 138(8):1493-1499, 2011
  14. Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW and Takahashi T. “Serotonin mediates cross-modal reorganization of cortical circuits.” Neuron 69(4):780-792, 2011
  15. Takemoto K, Kuranaga E, Tonoki A, Nagai T, Miyawaki A and Miura M “Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo.“ Proc Natl Acad Sci U S A. 104(33):13367-13372, 2007 LINK
  16. Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, Kobayashi M, Hayashi S and Miura M “Drosophila IKK-Related Kinase regulates non-apoptotic function of caspases via degradation of IAPs.” Cell 126(3):583-596, 2006
  17. Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H and Miura M “Drosophila caspase transduces Shaggy/GSK-3b kinase activity in neural precuorsor development.” EMBO J. 24(21):3793-3806, 2005
  18. Takemoto K, Nagai T, Miyawaki A and Miura M “Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects.” J.Cell Biol. 160(2):235-243, 2003 LINK
  19. Uetsuki T, Takemoto K, Nishimura I, Okamoto M, Niinobe M, Momoi T, Miura M and Yoshikawa K “Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein.” J.Neurosci. 19(16):6955-6964, 1999

Review

  1. Takemoto K "Optical manipulation of molecular function by chromophore-assisted light inactivation." Proc Jpn Acad Ser B Phys Biol Sci., 97(4):197-209, 2021
  2. Yamaguchi Y, Kuranaga E, Nakajima Y, Koto A, Takemoto K and Miura M. “In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe. Regulated Cell Death.” Methods Enzymol. 544:299-325, 2014