Department of Molecular Pathobiology

Selected recent publications:


  1. Park EJ*, Myint PK*, Appiah MG, Worawattananutai P, Inprasit J, Prajuabjinda O, Soe ZY, Gaowa A, Kawamoto E, Shimaoka M. Ligand-competent fractalkine receptor is expressed on exosomes. Biochem Biophys Rep 2021 Feb 2;26:100932.
  2. Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto W, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M. Sepsis induces deregulation of IL-13 production and PD-1 expression in lung group 2 innate lymphoid cells. Shock 2021 Mar 1;55(3):357-370
  3. Appiah MG, Park EJ, Darkwah S, Kawamoto E, Akama Y, Gaowa A, Kalsan M, Ahmad S, Shimaoka M. Intestinal epithelium-derived luminally released extracellular vesicles in sepsis exhibit the ability to suppress TNF-alpha and IL-17A expression in mucosal inflammation Int J Mol Sci 2020. Nov 10;21(22):8445
  4. Ito-Masui A, Kawamoto E, Nagai Y, Takagi Y, Ito M, Mizutani N, Yano K, Yano K, Imai H, Shimaoka M. Feasibility of Measuring Face-to-Face Interactions Among ICU Healthcare Professionals Using Wearable Sociometric Badges. Am J Respir Crit Care Med. 2020 Jan 15;201(2):245-247
  5. Park EJ, Prajuabjinda O, Soe ZY, Darkwah S, Appiah MG, Kawamoto E, Momose F, Shiku H, Shimaoka M. Exosomal regulation of lymphocyte homing to the gut. Blood Adv. 2019 Jan 8;3(1):3656-3666.
  6. Soe ZY, Prajuabjinda O, Myint PK, Gaowa A, Kawamoto E, Park EJ, Shimaoka M. Talin-2 regulates integrin functions in exosomes. Biochem Biophys Res Commun. 2019 Mar 14. pii: S0006-291X(19)30404-8. doi: 10.1016/j.bbrc.2019.03.027. [Epub ahead of print]
  7. Kawamoto E, Masui-Ito A, Eguchi A, Soe ZY, Prajuabjinda O, Darkwah S, E Park EJ, Imai H, Shimaoka M. Integrin and PD-1 ligand expression on circulating extracellular vesicles in systemic inflammatory response syndrome and sepsis. Shock. 2019 Jul;52(1):13-22. [Epub ahead of print]
  8. Darkwah S, Nago N, Appiah MG, Kawamoto E, Shimaoka M, Park EJ. Differential roles of dendritic cells in expanding CD4 T cells in sepsis. Biomedicines 2019 18;7(3) E52
  9. Okamoto T, Takagi Y, Kawamoto E, Park EJ, Usuda H, Wada K, Shimaoka M. Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression. Exp Cell Res. 2018 Jun 15;367(2):264-273.
  10. Okamoto T, Kawamoto E, Takagi Y, Akita N, Hayashi T, Park EJ, Suzuki K, Shimaoka M. Gap junction-mediated regulation of endothelial cellular stiffness. Sci Rep. 2017 Jul 21;7(1):6134
  11. Kawamoto E, Okamoto T, Takagi Y, Honda G, Suzuki K, Imai H, Shimaoka M. LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. Biochem Biophys Res Commun. 2016 473(4):1005-12


  1. Kawamoto E, Park EJ, Shimaoka M. Methods to study integrin functions on exosomes. Methods Mol Biol. 2021;2217:265-281.
  2. Park EJ, Myint PK, Ito A, Appiah MG, Darkwah S, Kawamoto E, Shimaoka M. Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights into the Multifaceted Roles of an Emerging Ligand Irisin. Front Cell Dev Biol 2020 Oct 26;8:588066
  3. Myint PK, Park EJ, Gaowa A, Kawamoto E, Shimaoka M. Targeted remodeling of cancer and immune cell homing niches by exosomal integrins. Diagn. Pathol 2020 Apr 18;15(1):38
  4. Shimaoka M, Kawamoto E, Gaowa A, Okamoto T, Park EJ. Connexins and Integrins in Exosomes. Cancers 2019 Jan 17;11(1)
  5. Park EJ, Appiah MG, Myint PK, Gaowa A, Kawamoto E, Shimaoka M. Exosomes in Sepsis and Inflammatory Tissue Injury. Curr Pharm Des. 2019 (in press)
  6. Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 Apr 1;29(4);157-163.
  7. Park EJ, Yuki Y, Kiyono H, Shimaoka M. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015 Jul 8;22:51.