三重大学循環器・腎臓内科学　心不全・心機能チーム



大西勝也 Onishi K.

  1. Takamura T, Onishi K, Sugimoto T, Kurita T, Fujimoto N, Dohi K, Tanigawa T, Isaka N, Nobori T, Ito M. Patients with a Hypertensive Response to Exercise Have Impaired Left Ventricular Diastolic Function. Hypertension Research 2008 in press.
  2. Motoyasu M, Kurita T, Onishi K, Sakuma H. Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging. Circ J 2008 in press.
  3. Kato S, Onishi K, Yamanaka T, Takamura T, Dohi K, Yamada N, Wada H, Nobori T, Ito M. Exaggerated Hypertensive Response to Exercise in Patients with Diastolic Heart Failure. Hypertension Research 2008 in press.
  4. Dohi K, Onishi K, Gorcsan J 3rd, Lopez-Candales A, Takamura T, Ota S, Yamada N, Ito M. Role of Radial Strain and Displacement Imaging to Quantify Wall Motion Dyssynchrony in Patients with Left Ventricular Mechanical Dyssynchrony and Chronic Right Ventricular Pressure Overload. Am J Cardiol. 2008 in press.
  5. Kurita T, Onishi K, Ogawa T, Kasai A, Sakuma H, Ito M. A case of clover-shaped left ventricular non-compaction. Eur Heart J. 2007 Oct 30.
  6. Nishioka T, Suzuki M, Onishi K, Takakura N, Inada H, Yoshida T, Hiroe M, Imanaka-Yoshida K. Eplerenone attenuates myocardial fibrosis in the angiotensin II induced hyoertensive mouse: Involvement of Tenascin-C induced by aldosterone-mediated inflammation. J Cardiovasc Pharmacol. 2007;49:261-268.
  7. Terasaki F, Okamoto H, Onishi K, Sato A, Shimomura H, Tsukada B, Imanaka-Yoshida K, Hiroe M, Yoshida T, Kitaura Y, Kitabatake A, and Study Group for Intractable Diseases by a Grant from the Ministry of Health, Labor and Welfare of Japan. Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. Circ J. 2007;71:327-330.
  8. Kurita T, Onishi K, Motoyasu M, Kitamura T, Takamura T, Fujimoto N, Tanabe M, Dohi K, Tanigawa T, Isaka N, Ito M, Sakuma H. Two cases of dilated cardiomyopathy with right ventricular wall degeneration demonstrated by late gadolinium enhanced MRI. Int J Cardiol. 2007 Aug 7.
  9. Kurita T, Onishi K, Dohi K, Tanabe M, Fujimoto N, Tanigawa T, Setsuda M, Isaka N, Nobori T, Ito M. Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration. Eur J Heart Fail. 2007;9:637-643.
  10. Takamura T, Dohi K, Onishi K, Kurita T, Tanabe M, Tanigawa T, Isaka N, Ito M. Improvement of left ventricular mechanical dyssynchrony associated with restoration of left ventricular function in a patient with fulminant myocarditis and complete left bundle branch block. Int J Cardiol. 2007 Apr 11.
  11. Kurita T, Kitamura T, Yamanaka T, Tanabe M, Dohi K, Tanigawa T, Onishi K, Ito M, Isaka N, Nakano T. Antique SVG with two humps: a case of two giant aneurysms of single saphenous vein bypass graft. Int J Cardiol. 2007;116:e68-70.
  12. Hirabayashi T, Tanabe M, Onishi K, Tanigawa T, Kitamura T, Yamada N, Ito M, Isaka N, Nakano T. Cardiac malignant lymphoma with atrial arrhythmias. Int J Cardiol. 2007;114:E42-44.
  13. Yamanaka T, Onishi K, Tanabe M, Dohi K, Funabiki-Yamanaka K, Fujimoto N, Kurita T, Tanigawa T, Kitamura T, Ito M, Nobori T, Nakano T. Force- and relaxation-frequency relations in patients with diastolic heart failure. Am Heart J. 2006;152:966.e1-7.
  14. Yamanaka-Funabiki K, Onishi K, Tanabe M, Dohi K, Ito M, Ohte N, Nobori T, Nakano T. Single beat determination of regional myocardial strain measurements in patients with atrial fibrillation. J Am Soc Echocardiogr. 2006;19:1332-1337.
  15. Abe Y, Wada H, Tomatsu H, Sakaguchi A, Nishioka J, Yabu Y, Onishi K, Nakatani K, Morishita Y, Oguni S, Nobori T. A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF). Thromb Res. 2006;118:463-469.
  16. Tanabe M, Onishi K, Dohi K, Kitamura T, Ito M, Nobori T, Nakano T. Assessment of left ventricular systolic function in patients with chronic atrial fibrillation and dilated cardiomyopathy using the ratio of preceding to prepreceding R-R intervals. Int J Cardiol. 2006;108:197-201.
  17. Sato F, Kitamura T, Kongo M, Okinaka T, Onishi K, Ito M, Isaka N, Nakano T. Newly diagnosed acute aortic dissection: characteristics, treatment modifications, and outcomes. Int Heart J. 2005;46:1083-1098.
  18. Nakajima K, Onishi K, Dohi K, Tanabe M, Kurita T, Yamanaka T, Ito M, Isaka N, Nobori T, Nakano T. Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels. Int J Cardiol. 2005;104:332-337.
  19. Fujimoto N, Onishi K, Tanabe M, Dohi K, Funabiki K, Kurita T, Yamanaka T, Nakajima K, Ito M, Nobori T, Nakano T. Nitroglycerin improves left ventricular relaxation by changing systolic loading sequence in patients with excessive arterial load. J Cardiovasc Pharmacol. 2005;45:211-216.
  20. Ogawa E, Okinaka T, Motoyasu M, Tanabe M, Iwasaki H, Kitamura T, Onishi K, Isaka N, Nakano T. A case of acute myocardial infarction caused by left main trunk disease with dilated cardiomyopathy. Int J Cardiol. 2005;98:507-508.
  21. Funabiki K, Onishi K, Tanabe M, Kuru S, Konagaya M, Sato F, Ito M, Nakano T. Electron microscopic findings of cardiomyopathy with limb girdle muscular dystrophy. Int J Cardiol. 2005;98:161-162.
  22. Tanabe M, Onishi K, Dohi K, Funabiki K, Koji T, Kitamura T, Ito M, Nobori T, Nakano T. Change in filling pattern with preload reduction reflects left ventricular relaxation. Int J Cardiol. 2005;98:67-72.
  23. Matsumoto T, Wada H, Nobori T, Nakatani K, Onishi K, Nishikawa M, Shiku H, Kazahaya Y, Sawai T, Koike K, Matsuda M. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation. Clin Appl Thromb Hemost. 2005;11:391-400.
  24. Wada H, Sakakura M, Kushiya F, Nisikawa M, Onishi K, Nakatani K, Shiku H, Nobori T. Thrombomodulin accelerates activated protein C production and inhibits thrombin generation in the plasma of disseminated intravascular coagulation patients. Blood Coagul Fibrinolysis. 2005;16:17-24.
  25. Zhang ZS, Cheng HJ, Onishi K, Ohte N, Wannenburg T, Cheng CP. Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther. 2005;315:1203-1211.
  26. Tsuji A, Tanabe M, Onishi K, Kitamura T, Okinaka T, Ito M, Isaka N, Nakano T. Intravascular hemolysis in aortic stenosis. Intern Med. 2004;43:935-938.
  27. Fujimoto N, Onishi K, Tanabe M, Koji T, Omichi C, Kato S, Kawasaki A, Nakano T, Ito M. Two cases of giant aneurysm in coronary-pulmonary artery fistula associated with atherosclerotic change. Int J Cardiol. 2004;97:577-578.
  28. Funabiki K, Onishi K, Dohi K, Koji T, Imanaka-Yoshida K, Ito M, Wada H, Isaka N, Nobori T, Nakano T. Combined angiotensin receptor blocker and ACE inhibitor on myocardial fibrosis and left ventricular stiffness in dogs with heart failure. Am J Physiol Heart Circ Physiol. 2004;287:H2487-2492.
  29. Onishi K, Dohi K, Koji T, Funabiki K, Kitamura T, Imanaka-Yoshida K, Ito M, Nobori T, Nakano T. Candesartan prevents myocardial fibrosis during progression of congestive heart failure. J Cardiovasc Pharmacol. 2004;43:860-867.
  30. Tanabe M, Onishi K, Hiraoka N, Kitamura T, Okinaka T, Ito M, Isaka N, Nakano T. Bilateral giant coronary aneurysms diagnosed non-invasively by dynamic magnetic resonance imaging. Int J Cardiol. 2004;94:341-342.
  31. Tanabe M, Onishi K, Kitamura T, Okinaka T, Ito M, Isaka N, Hioki I, Onoda K, Yada I, Nakano T. Effective cardiac resynchronization after Dor procedure and mitral annuloplasty. Can J Cardiol. 2004;20:449-451.
  32. Tanabe M, Onishi K, Dohi K, Ito M, Nakano T, Suga H. Alternans decay of postextrasystolic potentiation in human left ventricle. Jpn J Physiol. 2004;54:87-91.
  33. Motoyasu M, Sakuma H, Iwasaki H, Onishi K, Okinaka T, Isaka N, Takeda K, Nakano T. A case of inverted left atrial appendage mimicking a tumor. J Comput Assist Tomogr. 2003;27:501-504.
  34. Koji T, Onishi K, Dohi K, Okamoto R, Tanabe M, Kitamura T, Ito M, Isaka N, Nobori T, Nakano T. Addition of angiotensin II receptor antagonist to an ACE inhibitor in heart failure improves cardiovascular function by a bradykinin-mediated mechanism. J Cardiovasc Pharmacol. 2003;41:632-639.
  35. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res. 2003;92:411-418.
  36. Kitamura T, Onishi K, Dohi K, Okinaka T, Ito M, Isaka N, Nakano T. Circadian rhythm of blood pressure is transformed from a dipper to a non-dipper pattern in shift workers with hypertension. J Hum Hypertens. 2002;16:193-197.
  37. Noda A, Wada H, Kusiya F, Sakakura M, Onishi K, Nakatani K, Gabazza EC, Asahara N, Tsukada M, Nobori T, Shiku H. Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular coagulation. Clin Appl Thromb Hemost. 2002;8:265-271.
  38. Mizuno O, Onishi K, Dohi K, Motoyasu M, Okinaka T, Ito M, Isaka N, Nakano T. Effects of therapeutic doses of human atrial natriuretic peptide on load and myocardial performance in patients with congestive heart failure. Am J Cardiol. 2001;88:863-866.
  39. Isaka N, Yamada N, Araki S, Onishi K, Motoyasu M, Okinaka T, Ito M, Nakano T. Multiple pulmonary emboli with pulmonary hypertension caused by effort thrombosis and effective balloon venoplasty of the subclavian vein. Jpn Circ J. 2001;65:920-922.
  40. Dohi K, Onishi K, Kitamura T, Okinaka T, Ito M, Isaka N, Nakano T. Functional role of endogenous endothelin-1 in congestive heart failure treated with angiotensin II receptor antagonist. Jpn J Physiol. 2001;51:445-453.
  41. Cheng HJ, Zhang ZS, Onishi K, Ukai T, Sane DC, Cheng CP. Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium. Circ Res. 2001;89:599-606.
  42. Cheng CP, Ukai T, Onishi K, Ohte N, Suzuki M, Zhang ZS, Cheng HJ, Tachibana H, Igawa A, Little WC. The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure. Am J Physiol Heart Circ Physiol. 2001;280:H1853-1860.
  43. Kitamura T, Onishi K, Dohi K, Okinaka T, Isaka N, Nakano T. The negative inotropic effect of beta3-adrenoceptor stimulation in the beating guinea pig heart. J Cardiovasc Pharmacol. 2000;35:786-790.
  44. Kitamura T, Onishi K, Nakano T. [Treatment of heart failure to improve the prognosis] Nippon Naika Gakkai Zasshi. 1999;88:416-22.
  45. Onishi K, Ohno M, Little WC, Cheng CP. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther. 1999;288:1214-1222.
  46. Cheng CP, Onishi K, Ohte N, Suzuki M, Little WC. Functional effects of endogenous bradykinin in congestive heart failure. J Am Coll Cardiol. 1998;31:1679-1686.
  47. Onishi K, Sekioka K, Ishisu R, Abe Y, Tanaka H, Nakamura M, Ueda Y, Nakano T. MCI-154, a Ca2+ sensitizer, decreases the oxygen cost of contractility in isolated canine hearts. Am J Physiol. 1997;273:H1688-695.
  48. Abe Y, Sekioka K, Ishisu R, Onishi K, Ueda Y, Nakano T. Restoration of ischemic contractile failure of indo-1-loaded guinea pig heart by a calcium sensitizer, MCI-154. J Pharmacol Exp Ther. 1996;279:47-55.
  49. Ishisu R, Abe Y, Onishi K, Sekioka K, Nakano T. Differential effects of EMD-53998 on calcium-pressure relationship in normal and ischemic guinea pig heart. Am J Physiol. 1996;271:H311-319.
  50. Onishi K, Sekioka K, Ishisu R, Tanaka H, Nakamura M, Ueda Y, Nakano T. Decrease in oxygen cost of contractility during hypocapnic alkalosis in canine hearts. Am J Physiol. 1996;270:H1905-1913.
  51. Ishisu R, Abe Y, Onishi K, Ueda Y, Sekioka K, Nakano T. Changes in calcium transient and left ventricular function during positive inotropic stimulation and myocardial ischemia in indo-1-loaded beating guinea pig heart. J Pharmacol Toxicol Methods. 1996;35:55-61.
  52. Abe Y, Ishisu R, Onishi K, Sekioka K, Narimatsu A, Nakano T. Calcium sensitization in perfused beating guinea pig heart by a positive inotropic agent MCI-154. J Pharmacol Exp Ther. 1996;276:433-439.